In-depth article by Dr. Fabrizio David , regenerative medicine specialist at Image Regenerative Clinic. Supporting NAD (Nicotinamide Adenine Dinucleotide) levels through targeted IV therapies is now considered one of the most promising strategies in the field of longevity. This isn’t a passing trend, but a clinical approach backed by growing scientific evidence, capable of enhancing cellular energy, mitochondrial function, DNA repair, and oxidative stress response—key processes in slowing biological aging. Like any truly effective therapy, NAD requires careful medical assessment, personalized protocols, and a structured clinical setting to ensure real, safe, and lasting results. Not a Miracle Cure, But a Powerful Tool NAD is not an over-the-counter supplement or a one-size-fits-all solution. It’s a vital molecule for cellular metabolism that naturally declines with age and in the presence of chronic conditions. Restoring or supplementing its levels can translate into increased vitality, improved stress management, faster recovery, and enhanced cognitive and physical performance. But timing, dosage, and method of administration are crucial—and must always be determined under expert medical guidance. At Image Regenerative Clinic, every treatment begins with a comprehensive analysis of the patient’s metabolic and inflammatory status, including: Complete hematochemical and metabolic panel; Evaluation of key micronutrients involved in NAD synthesis (vitamin B3, B12, folic acid, vitamin D, zinc); Markers of oxidative stress and inflammation; Indicators of mitochondrial function; Only through this detailed workup can we determine whether NAD IV therapy is appropriate and set up a protocol that is truly effective. NAD IV Therapy and an Integrated Approach When indicated, intravenous NAD therapy allows for rapid and direct absorption, with noticeable effects often after just a few sessions. Depending on individual needs, it may be combined with custom infusions of vitamins, minerals, amino acids, and antioxidants, all tailored to the patient’s specific metabolic profile. This therapeutic strategy is part of a broader, holistic program that may include: Nutritional optimization Targeted physical activity Stress management strategies Continuous long-term monitoring Why Choose a Clinical Setting In a world where everything seems readily available, what makes the difference is the context. NAD IV therapies are not treatments to be improvised. They require medical expertise, structured protocols, and meticulous follow-up. Only in a specialized clinic like Image can patients receive the level of care needed to ensure safety, efficacy, and true personalization. Longevity is about making informed choices—not chasing miracles. Investing in your long-term health means relying on structured, science-based programs guided by clinical insight. When used consciously and under expert supervision, NAD can become an extraordinary ally .

Reading time: 5 minutes From unhealthy longevity to healthy longevity: a guided path, not a miracle How new therapeutic tools, lifestyle habits, and medical monitoring can help us live better and longer In recent years, the concept of healthy longevity has taken center stage in medical and societal conversations. It's no longer just about adding years to life: the challenge is to add life to years—by preventing chronic diseases, slowing degenerative processes, and maintaining mental and physical balance. But what can we do when the body begins to slide toward a condition of unhealthy longevity? The answer is not a shortcut, but a multidisciplinary path. That’s exactly the premise behind the Weight Loss Body Program developed by Image Regenerative Clinic —a structured approach to regaining health and vitality through a personalized, integrated program under strict medical supervision. Healthy longevity: a daily construction As explained in the “Code of Healthy Longevity” , aging can be modulated. Proper nutrition, physical activity—especially strength training—restorative sleep, stress management, and targeted supplementation (vitamin D, Omega-3s) are essential to slow the inflammatory processes that underlie many chronic and degenerative diseases. A study published in Nature Aging showed that combining vitamin D, Omega-3s, and physical exercise can slow biological aging, even influencing epigenetic markers ( Nutrienti e Supplementi, 2023 ). Similarly, Omega-3 supplementation has proven useful in preventing autoimmune diseases and low-grade silent inflammation ( Nutrienti e Supplementi, 2022 ). When lifestyle is not enough: the role of new molecules In some cases, despite best efforts, the body can no longer respond effectively. You enter a grey area marked by excess weight, sleep apnea, muscle loss (sarcopenia), and rising inflammation markers . Here, advanced pharmacological tools—under strict medical supervision—can be helpful. Drugs like semaglutide (Ozempic®) and tirzepatide (Mounjaro®) , originally developed for type 2 diabetes, have shown revolutionary potential for healthy longevity , thanks to their ability to: Significantly and sustainably reduce body weight Improve insulin sensitivity Regulate appetite and reduce caloric intake Improve inflammation markers Act on multiple target organs (liver, kidneys, central nervous system) According to a study published in the New England Journal of Medicine , tirzepatide led to a 22.5% reduction in body weight in people with obesity—greater than the reduction seen with semaglutide ( NEJM, 2022 ). Moreover, an analysis published by Quotidiano Sanità shows that, when used appropriately, these molecules also provide added benefits for cardiovascular, hepatic, and neurodegenerative health , as well as improved sleep quality in people suffering from obstructive sleep apnea ( Quotidiano Sanità, 2024 ). Real limits, avoidable risks These drugs are not miracle pills. Used outside a structured framework, they can lead to rapid weight regain—often at the expense of muscle mass . This is especially risky in older adults, where sarcopenia is one of the key threats to healthy aging. A study published by SIO Obesità emphasizes the importance of combining these therapies with resistance training to preserve muscle tissue and support metabolic health ( SIO Obesità, 2023 ). Image Regenerative Clinic: an integrated protocol for conscious longevity To prevent misuses and risks, Image Regenerative Clinic has developed a personalized Weight Loss Body Program that includes: Comprehensive medical evaluation Tailored nutritional support Targeted physical training (especially strength exercises) Innovative therapies only when needed and always under medical supervision Regular follow-ups to ensure stability, safety, and long-term results The goal is not simply to “lose weight” but to restore health , slow aging , and prevent chronic diseases associated with unhealthy longevity. Each intervention is part of a larger, individualized framework designed for long-term balance and well-being. No miracles, just conscious choices Ozempic® and Mounjaro® are powerful tools, but only become truly effective when integrated into a structured, medically guided journey. Used in isolation, without a complete lifestyle reset, the risk of relapse is high. True healthy longevity does not come from a single drug. It stems from the smart combination of prevention, science, and an integrated vision of health . https://www.youtube.com/watch?v=f2pSXS7ArtY And this is exactly where the real transformation begins.

Prevention is an individual responsibility, while the State is tasked with managing illness. In today’s context, where healthcare systems are often focused more on managing emergencies than on prevention, it becomes essential to rethink our relationship with health. Each of us has a duty to act early, adopting conscious behaviors and investing in our own longevity. Prevention is not a luxury, but a personal responsibility. The State can and must take care of treating illness, but the foundation of lasting well-being starts with us. Healthy longevity doesn’t mean never getting sick, but rather understanding and anticipating. It’s not about chasing the utopia of a disease-free life, but about shifting the moment when illnesses appear—and most importantly, reducing their impact—through a proactive and personalized approach. Healthy longevity means living longer while maintaining energy, mental clarity, physical functionality, and quality of life. It’s a vision that brings together science, technology, and a culture of wellness. Biomarker analysis is the first step toward a new health paradigm. Thanks to increasingly advanced technologies, it is now possible to perform a detailed analysis of a wide range of biomarkers—biological parameters that reveal the condition of our body and the predisposition to develop certain diseases. This type of early diagnosis enables us to intervene not only promptly, but most of all in a targeted and personalized way. But how can we truly talk about longevity without starting from an initial assessment of our biological state? Without understanding the starting point, any strategy risks being generic, ineffective, and disconnected from the reality of each individual. Biomarkers represent the foundational map on which to build an authentic, personalized, and measurable path to well-being over time. But after the analysis, action is essential: targeted therapies, specialized structures, competent professionals. This is where centers like Image Regenerative Clinic come into play—a leading hub for aesthetic and regenerative medicine focused on longevity. After obtaining a comprehensive overview of health status through biomarker analysis, Image is able to develop personalized therapeutic programs, based on innovative protocols, advanced technologies, and the expertise of highly qualified professionals. These programs are reassessed periodically to adapt to the body’s evolution and ensure lasting results. A dynamic and integrated approach, perfectly aligned with the themes of the Milan Longevity Forum. The Milan Longevity Summit , currently taking place in Milan, highlights these very concepts: the importance of personalized prevention, the integration of science and wellness, and the need to create health ecosystems. Image Regenerative Clinic fits perfectly within this vision, offering a concrete and operational model to translate longevity theories into real, accessible, and personalized therapeutic strategies.

Milan and New York: two capitals of elegance, style, and innovation. If you're planning a trip to the Big Apple, there’s one exclusive address you simply can’t miss: the dangene Medical SPA. Located in the heart of Manhattan, this prestigious skincare and regenerative treatment center is a must-visit for those who seek tailor-made beauty solutions, designed to rejuvenate the skin and enhance its natural glow. Luxury Skincare, Customized for You Founded by our dear friend Dangene , this iconic beauty destination offers cutting-edge facial and body treatments , combining technologies such as laser therapy, LED, oxygen infusion, and cellular treatments . Much like the philosophy behind Image Regenerative Clinic , Dangene Institute is all about personalized beauty journeys , focusing on long-term skin health and anti-aging solutions. An Exclusive Beauty Retreat in Manhattan Nestled within the prestigious CORE Club , dangene Medical SPA is more than just a skincare clinic—it’s an ultra-private, luxury experience designed for those who demand the best. Whether you're visiting New York for business or pleasure, take a moment for yourself: a signature skincare transformation by Dangene is the ultimate self-care indulgence. Her elite team will guide you toward the most effective treatments, delivering visible, long-lasting results . Connecting Milan and New York in the Name of Excellence At Image Regenerative Clinic , we believe in borderless beauty and international expertise . That’s why we invite you to experience the dangene Medical SPA firsthand and treat yourself to a rejuvenating session with Dangene and her top-tier team. 📍 Where to find them? dangene Medical SPA – 711 5th Avenue, New York, NY 10022 📞 +1 (212) 249 8172 📧 appointment@dangene.com If you visit, let us know about your experience! ✨

There is a special energy that comes with this time of the year: spring. The first rays of sunshine warm the skin, the air is filled with the scent of renewal and lightness, and as nature awakens, we naturally feel the desire for freshness, radiance, and vitality. It is the season when we long to refresh ourselves, to shed the signs of winter fatigue, and to rediscover a more relaxed and serene face. And this is precisely the ideal time for a treatment that naturally revitalizes and enhances facial harmony: Botox. Springtime for Your Face: Why Is Botox the Perfect Treatment for This Season? Just as spring is the season of renewal, Botox is the treatment that allows the face to blossom, freeing itself from tension and the tired expressions that winter has left behind. After months of cold weather, dull skin, and features marked by stress and fatigue, the desire for lightness translates into the need for a brighter, more refreshed, and youthful appearance. This is where Botox comes into play—it not only smooths expression lines but also restores harmony and energy to the face, reflecting the fresh vitality of spring. Over 6 million people worldwide choose Botox each year, with more than 300,000 procedures annually in Italy alone. It is not just a trend but a conscious choice for those who want to take care of their appearance wisely. Why wait for wrinkles to deepen when they can be prevented naturally? Smoother Skin, a Lighter Mood: Botox Is Also Good for the Mind If spring is the season of positivity, Botox is its perfect ally. Scientific studies show that Botox not only improves aesthetics but also has a direct impact on emotional well-being. By reducing frown lines and tense expressions, the brain receives fewer stress signals. A study published in the Journal of Psychiatric Research confirmed that patients treated with Botox in the area between the eyebrows experienced a significant reduction in depressive symptoms, thanks to the facial feedback mechanism. Imagine the feeling of lightness on a spring day, when the sun kisses your skin and the blue sky fills you with good vibes. That’s exactly how Botox works for your face: it removes tension, relaxes expressions, and makes you look as refreshed and at peace as you feel when breathing in the crisp April air. Not Just One Technique: Botox Is an Art, Not Just a Treatment Just as every spring has its own unique shades, Botox can be applied in different ways. It’s not about "freezing" the face but enhancing it naturally. There are customized approaches like Baby Botox , which uses micro-doses for an ultra-natural effect, ideal for those who want to start prevention while maintaining full facial expressiveness. Every face needs a tailored treatment, and only an expert doctor can enhance it with the right balance. The Areas Where Botox Can Awaken Your Beauty Just as spring brings nature to life in every little detail, Botox can be applied in different facial areas to restore harmony and radiance : Spring Means Safety and Lightness: Botox Is Safe, But Experience Matters Just as you trust professionals for the best skincare treatments in spring, Botox should only be entrusted to experienced doctors. Incorrect application can lead to unnatural results, such as asymmetry or stiffness, while a well-executed treatment is only noticeable in the freshness and harmony of the face. Botox is not a one-size-fits-all procedure—it is an art of precision. Only those with deep knowledge of facial anatomy and a refined aesthetic sense can deliver the perfect outcome. An Intelligent Choice for Both Men and Women: Why Wait? Spring is the season of renewal—why not refresh your face as well? Botox is a smart choice for both women and men , as a fresh and relaxed look conveys well-being, confidence, and positivity. More and more professionals are turning to aesthetic medicine to improve their appearance in a discreet and refined way. Conclusion: Let Go of the Myths and Let Your Face Blossom Spring teaches us that beauty is a balance between freshness and harmony. When performed by skilled hands, Botox does not alter your features but enhances your natural expressions, making you look younger, more radiant, and relaxed. If you’ve had doubts or hesitations until now, ask yourself: how important is it for you to look as vibrant as you feel inside? Now you have two choices: keep waiting, or give your skin the freshness and glow it deserves. What will you choose? 🌸

From March 21 to 29, 2025, Milan reaffirms its role as an international hub of science and innovation by hosting the Milan Longevity Summit. For ten days, Nobel Prize winners, world-renowned scientists, and pioneers in regenerative medicine will share their research on the most advanced strategies for living longer and healthier lives. Among the event’s key speakers are Shinya Yamanaka, 2012 Nobel Prize winner in Medicine for his discoveries on stem cells, and Venkatraman Ramakrishnan, 2009 Nobel Prize winner in Chemistry for his research on ribosome structure. Also attending is Prof. Camillo Ricordi, Emeritus Director of the Diabetes Research Institute (DRI) in Miami, known for his groundbreaking studies on cellular transplants and co-founder of Lipogems alongside Prof. Carlo Tremolada. The Summit benefits from the organizational and scientific contribution of Prof. Alberto Beretta, a world-renowned immunologist and co-founder of SoLongevity. Milan: Capital of Longevity and Economic Growth Milan is not only an international cultural and scientific center but is increasingly becoming a leading hub for longevity research. Attending events like the Milan Longevity Summit provides access to cutting-edge knowledge and insights into how science is redefining our future. Longevity is not just a biological challenge but also a powerful economic driver: living longer and healthier means reducing healthcare costs, keeping the population active for longer, and creating new investment opportunities in biotechnology, wellness, and regenerative medicine. Two Must-Attend Talks on March 29 The final day, March 29, will feature two high-value keynote speeches: Prof. Camillo Ricordi – "Longevity for All: The Interplay of Epigenetics and Environment" A deep dive into how epigenetics and the environment influence longevity and which strategies can help maximize our biological potential. Prof. Carlo Tremolada – "Regenerative And Enhancing Medicine: Advancing Health And Longevity" A focus on the latest technologies in regenerative medicine, particularly the role of mesenchymal stem cells in improving quality of life. Why Attend? Gain access to the latest scientific discoveries through world-class conferences and workshops. Understand the connection between science, economy, and well-being, and how longevity is reshaping the future of society. Experience Milan as a capital of innovation and health, a unique opportunity to engage with world-class experts. Participate in Longevity Labs, hands-on experiences in nutrition, exercise, and anti-aging strategies. Participation in the Milan Longevity Summit is free, but some events require registration. For more information and to register, visit the official website: www.milanlongevitysummit.org Don’t miss the chance to be part of an event that will change the way we think about health, longevity, and our future!

In recent years, scientific research has opened new frontiers in tissue regeneration, offering innovative solutions for the treatment of joint disorders, skin rejuvenation, and much more. One of the most advanced methods, backed by scientific research, is Lipogems® , a patented system developed by Professor Carlo Tremolada of Image Regenerative Clinic in Milan. This technology harnesses micro-fragmented adipose tissue (MFAT) , rich in mesenchymal stem cells and natural growth factors , to support tissue repair and regeneration in a safe, effective, and minimally invasive way. What are the Most Promising Clinical Applications of Lipogems®? Lipogems®: Innovation in Regenerative Medicine for Joints, Skin, and More Regenerative medicine is transforming the medical landscape, offering advanced solutions for various conditions. Among these innovations, the Lipogems® system stands out for its effectiveness and versatility . Developed and patented by Professor Carlo Tremolada at Image Regenerative Clinic in Milan, Lipogems® utilizes micro-fragmented adipose tissue to promote tissue regeneration across multiple medical fields. What is Lipogems®? Lipogems® is a technology that processes autologous adipose tissue through a closed and sterile system , without the use of enzymes or chemical substances. This method preserves the integrity of mesenchymal stem cells and pericytes , which play a crucial role in tissue regeneration. The result is a standardized-quality product , ready to be used in various clinical applications. Clinical Applications Orthopedics : Lipogems® is used in the treatment of osteoarthritis and tendinopathies , helping reduce pain and improve joint function . Beauty : In the aesthetic field, Lipogems® is applied for skin rejuvenation, volume correction, and overall skin quality improvement . Gynecology : The system is used to treat post-menopausal vulvovaginal atrophy , improving tissue elasticity and hydration . Coloproctology : Lipogems® shows potential in treating anal fistulas and fissures , offering a regenerative approach that promotes faster and less invasive healing compared to traditional methods. Crohn’s Disease : A clinical trial is currently underway at Sant'Orsola Hospital in Bologna , where Lipogems® is being studied for the treatment of perianal complications associated with Crohn’s disease. Chronic Wounds and Diabetic Foot : Lipogems® is used in the treatment of diabetic foot ulcers and other complex wounds , leveraging the regenerative properties of adipose tissue to accelerate healing and reduce infection risks . Lipogems® represents a breakthrough in regenerative medicine , offering effective and minimally invasive solutions for a wide range of conditions. Ongoing research and advancements in application techniques will further expand its potential, improving the quality of life for many patients .

The debate between acceptance and health In recent years, the concept of Body Positivity has gained popularity, promoting acceptance of all bodies and countering weight-related stigma. It's a positive principle that has helped valorize diversity and combat discrimination. However, in some cases, the evolution of this movement has led to an extreme view, where any discussion about health related to weight is perceived as an attack on individual freedom. This leads us to reflect on the importance of a balanced approach, where respect for oneself and others combines with awareness of health risks. It is therefore fundamental to distinguish between acceptance and well-being, understanding how body weight influences our overall health. Health cannot be sacrificed in the name of inclusivity. Obesity is not just an aesthetic issue, but a concrete risk factor for longevity and quality of life. Several studies have shown that being overweight increases the risk of chronic diseases such as type 2 diabetes, hypertension, cardiovascular diseases, and some types of cancer. The New England Journal of Medicine has highlighted that obesity can reduce life expectancy by up to ten years, depending on the severity of the case. These data help us understand how essential it is to address the issue of weight with a perspective based on science and long-term well-being, rather than on superficial judgments or radical ideologies. The role of science in weight management Within this complex discussion lies the Body Positivity movement, born with the intent to promote self-acceptance, fight discrimination, and value the diversity of bodies. However, in recent years, it has become radicalized to the point of challenging anyone who talks about weight loss, spreading the idea that promoting a healthy lifestyle equates to "fatphobia." This attitude risks dissuading people from making informed decisions for their health, leaving them trapped in conditions that compromise their quality of life. Accepting one's body doesn't mean ignoring the risks associated with obesity: true awareness comes from balance, that is, appreciating oneself without neglecting the impact that body weight has on metabolism, internal organs, and the ability to maintain optimal energy over time. Faced with this complexity, scientific research has developed solutions for weight control, aimed at improving quality of life without falling into extremism. Innovation has led to the creation of drugs such as Mounjaro (tirzepatide) and Wegovy (semaglutide), which have demonstrated their ability to promote weight loss in a safe and sustainable way, improving vital parameters such as blood glucose, cholesterol, and blood pressure. These solutions open new perspectives for those struggling with overweight and obesity, but they are not exempt from criticism. Some commentators have contested them, arguing that they contribute to reinforcing the stigma of obesity. However, it is essential to understand that these treatments are not an aesthetic solution, but medical tools that can significantly improve the health of those suffering from pathological obesity. The importance of a balanced approach Looking at the longest-lived societies in the world, we discover an interesting fact: weight management should not be seen as an imposition, but as an opportunity to live better and longer. Research on longevity shows that the populations of Blue Zones share a common aspect: maintaining a balanced body weight through healthy eating and constant physical activity. The benefits of an optimal BMI include better blood glucose control and diabetes prevention, reduced risk of cardiovascular diseases, lower levels of inflammation and oxidative stress, and increased vitality and quality of life. The discussion on weight and health cannot be reduced to an ideological clash between "skinny versus fat." The real goal must be well-being, based on informed choices supported by science. It's not about adhering to aesthetic standards imposed by society, but about living longer and better. Instead of fueling sterile debates, we should focus on what truly matters: a healthy, active life full of energy. At Image Regenerative Clinic, we adopt a scientific and personalized approach to help our patients achieve their maximum potential for well-being and longevity. We are ready to support you on this journey with advanced medical solutions and personalized strategies for your well-being.

50 and 60 years? They're the new 40! Today, women in their 50s and 60s live with energy and awareness, dedicated to their wellbeing and eager to take care of themselves. However, menopause brings physiological changes that can affect quality of life, including vaginal dryness, painful intercourse, urinary discomfort, and recurring inflammation. These symptoms are often neglected or considered inevitable, but science proves otherwise. Research conducted for Image Regenerative Clinic has highlighted how vaginal discomfort is perceived as a real but rarely discussed problem. Due to modesty or embarrassment, many women avoid discussing it, even with their partner, and seek solutions only when symptoms become limiting. It's time to change this approach and consider intimate health as an integral part of overall wellbeing. Lipogems: The Natural Solution for Intimate Wellness A study published in European Review for Medical and Pharmacological Sciences by Doctors Casarotti and Tremolada demonstrated the efficacy of Lipogems, an innovative treatment that harnesses the regenerative power of adipose tissue to improve vaginal mucosa hydration and elasticity. How Does Lipogems Work? Lipogems is a regenerative medicine treatment utilizing autologous adipose tissue to stimulate cellular renewal. The process begins with harvesting a small amount of fat, which is then purified and microfragmented to obtain a concentrate rich in mesenchymal cells. This preparation is subsequently injected into vaginal tissues, promoting natural and progressive regeneration. Documented benefits include increased elasticity and hydration of vaginal mucosa, enhanced sensitivity and comfort, and reduced dryness and pain during intercourse. Unlike other solutions, Lipogems offers long-term results through its ability to stimulate microcirculation and structural tissue renewal. Lipogems vs. Laser Therapy: The Real Difference Until now, laser therapy has been one of the most common techniques for treating vaginal atrophy, acting through thermal microlesions to stimulate collagen production. Although effective, many patients find it uncomfortable and with time-limited effects. The true difference between the approaches lies in vascular regeneration. While laser therapy is limited to superficial action on already compromised tissues, Lipogems promotes new blood vessel formation, improving microcirculation and ensuring stable, lasting tissue restoration. Prof. Carlo Tremolada's Commentary: "The laser approach creates a stimulating action on tissue that has already lost much of its regenerative capacity. Lipogems, however, works by enhancing microvascularization and tissue elasticity naturally and progressively. This means the improvement isn't just aesthetic or temporary, but structural and lasting. True regeneration." A New Vision for Intimate Health Vaginal health should be considered part of overall wellness, not exclusively linked to sexual function. Lipogems offers a comprehensive solution for intimate wellness, reducing dryness, irritation, and even recurrent cystitis. This scientifically advanced and completely natural approach uses no hormones, doesn't alter physiological balance, and exclusively utilizes the patient's own regenerative capabilities.

A device that combines microneedling and radiofrequency for skin regeneration, wrinkle reduction, texture improvement, and scar revision. By Dr. Fabrizio David, aesthetic physician at Image Regenerative Clinic. Mechanism of Action Vivace is a radiofrequency microneedle system that stimulates neocollagenesis through dermal-epidermal renovation. The device combines controlled microtrauma with precise thermal modulation both at the tip and along the needle. The procedure preserves epidermal and melanocyte integrity, preventing post-inflammatory hyperpigmentation. Clinical Indications The treatment is indicated for superficial and deep wrinkles, skin porosity, and post-acne scarring. It induces immediate tissue tightening with increased tissue tonicity and reduced erythema, with progressive results over time. Therapeutic Protocol Three annual sessions at 45-day intervals are recommended. The treatment is viable in all seasons, including on tanned skin and dark phototypes. The created microchannels facilitate transdermal absorption of active ingredients such as vitamins, polynucleotides, and botulinum toxin, enhancing their therapeutic efficacy.

To combat cellulite and significantly reduce orange-peel skin appearance. To improve skin tone through polynucleotides. Or to enhance microcirculation with ozone. Mesotherapy is a multifunctional technique for addressing various coexisting conditions. The optimal time to begin treatment isn't just before summer, but especially after returning from vacation. Insights from Dr. Fabrizio David, aesthetic physician at Image Regenerative Clinic. What is Mesotherapy? Mesotherapy involves injecting therapeutic substances through very fine needles into the treatment area. For legs and body treatments, these substances typically include lipolytic cocktails for localized fat deposits, anti-lipodystrophic agents for cellulite, or polynucleotides to restore elasticity to particularly dehydrated and wrinkled skin. The painless injections are administered at multiple points spaced half a centimeter apart. What conditions does Mesotherapy address? Mesotherapy non-invasively treats and improves common lower limb conditions, including orange-peel skin texture, cellulite, and water retention. When performed as localized oxygen-ozone therapy, it also addresses capillary visibility and microcirculation weakness. Why does Image recommend Mesotherapy? Mesotherapy should be viewed as a year-round maintenance routine rather than just a pre-summer treatment. Perfect legs aren't seasonal: they result from consistent care throughout the year. Post-summer is particularly crucial, when vacation benefits are still visible and maintaining results is easier. If summer indulgences have occurred, it's the ideal time for corrective treatment. Notably, mesotherapy can be combined with other treatments, and results are significantly enhanced within structured protocols. Our Skinny Legs program exemplifies this approach, combining shock wave sessions, targeted mesotherapy for edematous-fibro-sclerotic panniculopathy, and oxygen-ozone therapy.

Rhizarthrosis is a degenerative disease of the thumb joint, particularly painful and debilitating, primarily affecting women over 40 and during menopause. A clinical study demonstrates that Lipogems regenerative medicine not only resolves pain but promotes cartilage repair and progressive healing from rhizarthrosis. We discuss this with Image Regenerative Clinic experts, Professor Carlo Tremolada, Scientific Director, and Dr. Laura Loda, hand surgeon, who are the authors of the clinical study. Can rhizarthrosis be treated without surgery? In the clinical study conducted on 45 patients (36 females and 9 males aged 41-77 years) at Image Regenerative Clinic in Milan, Lipogems regenerative medicine with MFAT adipose tissue transplantation demonstrated promotion of cartilage healing in thumb joints affected by rhizarthrosis. The Lipogems autologous fat transplantation, performed through intra-articular injection, proved effective in both early-stage and advanced severe thumb osteoarthritis. Traditional therapies include conservative treatments (non-surgical) with intra-articular corticosteroid or hyaluronic acid injections, custom splints, physiotherapy, and surgical interventions (trapeziectomy, prosthesis, arthrodesis) indicated when conservative therapy proves ineffective. Both conservative and surgical treatments provide significant symptom relief but with functional limitations and cannot promote cartilage regeneration or prevent the underlying arthritic process. How does Lipogems regenerative therapy work for rhizarthrosis? Lipogems regenerative therapy for rhizarthrosis is performed through intra-articular injection of autologous adipose tissue harvested via minor liposuction from the patient's abdomen or thighs and microfragmented using a specific device (Lipogems - patented by Professor Carlo Tremolada). As demonstrated by extensive scientific literature, autologous adipose tissue contains high levels of progenitor cells (pericytes, mesenchymal stem cells, growth factors) which, when injected into the thumb joint, promote cartilage tissue formation. Additionally, the injected Lipogems tissue acts as a cushion for the worn joint, preventing direct contact and abrasion between articular surfaces, reducing pain. Study results demonstrate that following the post-operative rehabilitation program is essential for optimal regenerative treatment outcomes. Lipogems regenerative treatment can be repeated if rhizarthrosis symptoms recur, including treatment of the other hand or arthritic pain in other joints, without requiring repeated liposuction for autologous fat harvesting. Through Lipobank, patients can cryopreserve their fat tissue for future use.