Our Scientific Research | Image Regenerative Clinic Milan

At Image Milano, we are committed to pushing the boundaries of regenerative medicine through rigorous scientific research. Our clinic actively supports and participates in cutting-edge studies to enhance the understanding and clinical applications of microfragmented adipose tissue (MFAT) technology. Under the guidance of Professor Carlo Tremolada, the inventor of the Lipogems® technology, we collaborate with prestigious universities and research centers worldwide to explore new frontiers in regenerative therapy.

Our research network extends across Europe, including partnerships with:

University of Milan
University of Eastern Piemonte
University of Manchester (UK)
Carlo Besta Neurological Institute
Veterinary Hospital of Lodi

For a complete list of our scientific publications and research collaborations, please contact us.

Our research on regenerative medicine is developed in close collaboration with prestigious universities and international research centers, including the University of Milan, the University of Eastern Piedmont and the University of Manchester (UK).

Together with our scientists, these academic institutions carry out advanced studies to understand and optimize the therapeutic potential of microfragmented adipose tissue (MFAT), with a focus on tissue regeneration, angiogenesis, anti-inflammatory and antibacterial properties.

Thanks to an in-depth analysis of the secretome – the set of biomolecules released by MFAT – we explore the biological mechanisms that regulate cell growth, tissue repair and intercellular communication.

Our research focuses on:

Growth factors and cytokines, key regulators of cell proliferation and healing

Lipidomics, to understand the role of bioactive lipid mediators in regeneration

Exosomes, sophisticated vectors of biological signals between cells

Anti-inflammatory molecules, which modulate the immune response and promote healing

Angiogenic factors, essential for the formation of new blood vessels and tissue repair

These studies, published in prestigious scientific journals (Stem Cell Int. 2019, Vasc Cell 2016, Br J Anaesth. 2018

Scientific Research: Innovation that Redefines Regenerative Medicine

Scientific research is the pillar upon which medical progress is built, and Image embodies a cutting-edge vision that unites innovation and scientific rigor. Our commitment extends well beyond aesthetic medicine: we support and promote pioneering studies aimed at revolutionizing the very concept of care, from tissue regeneration to the fight against complex and degenerative pathologies.

The Pride of Image Research: A Tangible Excellence

What makes Image a point of reference is not only the high quality of treatments, but our constant dedication to scientific research, which allows us to transform laboratory discoveries into concrete clinical solutions. By deepening the most advanced mechanisms of regenerative medicine, we continuously refine our protocols to guarantee patients elite treatments, based on certified scientific evidence and cutting-edge technologies.

Our mission is not just an advertising slogan, but a real commitment: Image invests in and sponsors research that sets the pace of innovation, contributing to the evolution of regenerative medicine with increasingly effective, safe, and personalized solutions.

The Importance of Research for the Future of Medicine

This research represents a significant step towards a future where cancer treatments are increasingly personalized, effective, and less invasive. The use of MFAT as a drug carrier could open new avenues in the fight against cancer, offering new hope to patients with complex oncological diseases. Established scientific evidence (Alessandri G. et al., Journal of Controlled Release 2019, Cancers Basel 2021) and preclinical studies have demonstrated that adipose tissue, after being processed with the Lipogems® device, acquires the extraordinary ability to absorb and release chemotherapeutic drugs such as Taxol (PTX) in a localized manner. This process opens new perspectives in the fight against cancer, allowing for more effective and targeted therapeutic action.

Scientific Results and Clinical Developments

Preclinical studies have shown that MFAT loaded with PTX, once positioned in the vicinity of a tumor, is able to induce its regression.
Veterinary clinical trials, conducted in collaboration with Dr. Offer Zeira at the Veterinary Hospital of Lodi, have confirmed the effectiveness of the treatment on brain tumors in dogs.
Development of human clinical procedures: thanks to the collaboration between Image, Dr. Giulio Alessandri and neurosurgeons at the Carlo Besta Neurological Institute in Milan, the drafting of a clinical protocol to apply the MFAT-PTX treatment in glioblastoma therapy, one of the most aggressive and difficult-to-treat brain tumors, is in an advanced stage.

A New Approach to Regenerative Beauty

Initiated in early 2023 on the initiative of Dr. Elena Colombani, this research aims to create an autologous beauty cream derived from MFAT for the topical treatment of:

Wrinkles and signs of aging

Skin discolorations and imperfections

Stimulation of hair regrowth

The project explores the potential of MFAT in the formulation of products for aesthetic use that offer lasting and safe results, leveraging the regenerative properties of the patient's own cells.

Scientific Evidence and Research Developments

In vitro tests on human skin models to analyze the functional characteristics of MFAT, with particular attention to cell proliferation, inflammation and antioxidant activity.
Safety studies that have confirmed that products derived from the MFAT secretome do not stimulate the growth of tumor cells, ensuring safe use in aesthetic treatments.
Collaboration with lyophilization centers at the University of Eastern Piedmont and Perugia to develop a lyophilized MFAT product, capable of preserving its biological properties over time and allowing for prolonged and repeatable treatments.

Scientific Research

Advancing Regenerative Medicine Through Innovation

Collaborations and Publications

Our Research Focus Areas

Molecular Characterization of Regenerative Factors

Exploring the Science Behind Tissue Regeneration

Why Our Research Matters

Scientific Research: Innovation that Redefines Regenerative Medicine

The Pride of Image Research: A Tangible Excellence

Scientific Literature

Micro-fragmented adipose tissue - An innovative therapeutic approach: A narrative review

Micro fractured Adipose Tissue Graft (Lipogems), Regenerative Surgery and Potential Outcomes for Infectious and Cancer Diseases - Lipogems

Tissue engineering and future directions in regenerative medicine for knee cartilage repair: a comprehensive review - Lipogems

Technical considerations for isolated limb perfusion: A consensus paper - Lipogems

Acne Scars: Multimodal Treatment with Surgical Subdermal Plane Dissection, Microfragmented Adipose Tissue Infiltration and Deep CO2 Laser Resurfacing. Our Clinical Experience in 15 Clinical Cases Treated - Lipogems

Novel Approach in Rectovaginal Fistula Treatment: Combination of Modified Martius Flap and Autologous Micro-Fragmented Adipose Tissue - Lipogems

Effects of Autologous Microfragmented Adipose Tissue on Bone Healing: A Blinded, Prospective, Randomised Canine Clinical Trial - Lipogems

Microfractured lipoaspirate may help oral bone and soft tissue regeneration: a case report - Lipogems

Successful isolation of viable stem cells from cryopreserved microfragmented human adipose tissue from patients with knee osteoarthritis – a comparative study of isolation by tissue explant culture and enzymatic digestion - Lipogems

Case Report: Microfragmented Adipose Tissue Drug Delivery in Canine Mesothelioma: A Case Report on Safety, Feasibility, and Clinical Findings - Lipogems

Role of Autologous Fat Grafting in the Conservative Treatment of Fecal Incontinence in Children - Lipogems

Differences in exosome content of human adipose tissue processed by non-enzymatic and enzymaticmethods - Lipogems

MFAT as a Natural Drug Delivery System

Revolutionizing Cancer Treatment Approaches

The Importance of Research for the Future of Medicine

Scientific Results and Clinical Developments

Dermatological Applications of MFAT

Pioneering Autologous Skincare Solutions

A New Approach to Regenerative Beauty

Scientific Evidence and Research Developments