Dermatological Consultation

With summer just around the corner, taking care of your skin isn’t just a matter of aesthetics—it’s a matter of health. Discover how to prevent skin cancer with innovative treatments like ALA Photodynamic Therapy and Kleresca® photobiomodulation, available at Image. Protecting your skin, all year long especially in summer. Why skin cancer prevention matters as the warmer season approaches In a world where beauty and wellbeing are increasingly intertwined, Image Regenerative Clinic stands out as a trusted destination not only for aesthetics, but for skin health too. Our integrated approach combining aesthetic medicine, dermatology, and surgery allows us to provide patients with highly specialized, comprehensive, and personalized care. Medicine beyond beauty. As spring arrives and sun exposure increases, it’s important to shine a light on a crucial topic for skin health: the prevention of skin cancer. Among the most common types are basal cell carcinoma and squamous cell carcinoma—forms of skin cancer that, while often less aggressive than melanoma, should never be underestimated. The first step in prevention is awareness Non-melanoma skin cancers mainly affect photo-exposed areas—face, ears, neck, hands—and are more likely to develop in individuals with fair skin or a history of intense and prolonged sun exposure. That’s why prevention must begin before summer, with proper education and responsible behavior. The dermatological check-up: a simple act that makes all the difference Primary prevention is the most powerful ally in protecting your skin. Regular dermatology visits —especially in the presence of suspicious lesions, moles that change in shape, color or size, or small persistent scabs—are the most effective tool for early diagnosis. At Image Regenerative Clinic, prevention is a core part of a multidisciplinary approach to both skin health and beauty. Our specialists perform detailed mole mapping and targeted check-ups, even during times of year when the risks of sun exposure tend to be underestimated. Treatments: from non-invasive to surgical In the case of a skin cancer diagnosis, early treatment is key. At Image, a variety of therapeutic options are available—tailored to each patient and depending on the location and nature of the lesion. Among the non-invasive treatments , highlights include: ALA Photodynamic Therapy (aminolevulinic acid): a targeted and conservative treatment that uses a photosensitizing agent activated by a specific light source to selectively destroy abnormal cells. It is particularly effective for superficial or actinic lesions and helps prevent progression to more aggressive forms. Kleresca® Photobiomodulation, an innovative technology that stimulates the skin’s natural repair processes through clinically tested fluorescent light. It offers both preventive and regenerative benefits and can be used as part of a maintenance protocol—even following photodynamic therapy. When necessary, dermatologic surgery can be performed using refined techniques designed to achieve the best oncological and aesthetic outcome—especially important for tumors located in visible areas such as the face. Sun exposure with awareness Using sunscreen, wearing hats and sunglasses, avoiding sun exposure during peak hours—these are small everyday habits that can significantly contribute to prevention. But it’s only through a culture of continuous and conscious care that we can truly protect our skin. With summer on the horizon, choose to take care of yourself. Book your skin cancer prevention check-up at Image and consult with our specialists about a personalized protocol —which may include ALA Photodynamic Therapy and Kleresca® Photobiomodulation . Because your skin’s health is also your beauty . Image Regenerative Clinic – Medicine Beyond Beauty.

From Vanity Fair Italy Article Vanity Fair Italy recently published an in-depth look at Lipogems® , presenting it as the most effective method for skin reverse aging. This treatment, developed by Dr. Carlo Tremolada , represents one of the most advanced solutions in the field of aesthetic regenerative medicine. What is Lipogems® Lipogems® is a patented methodology approved by the FDA that leverages the principles of regenerative medicine. Initially developed to accelerate healing processes and recovery from sports injuries (also used by skier Sofia Goggia), it finds application in orthopedics for problems such as arthritis and tendonitis, and more recently in aesthetics for skin rejuvenation. The treatment is based on the body's self-healing principle, using the person's own adipose cells, particularly rich in stem cells, to activate regeneration in tissues where biological functions have slowed down. The Scientific Principle According to Dr. Tremolada , Lipogems® involves the grafting of active adult mesenchymal stem cells taken from the patient's fat. These cells, fundamental in the body's repair processes, are extracted through a patented device that reduces the size of adipose tissue without destroying its structure. The processed adipose tissue is rich in microvessels and pericytes (precursors of mesenchymal stem cells), which are then injected into areas where tissue regeneration needs to be reactivated. The Treatment Process The process begins with the extraction of adipose tissue that is processed with a specific device. This tissue, initially shaped like a "ripe raspberry," is progressively reduced through sharp filters that act as a sieve. The reduction occurs with the emission of high pressure, without air, protecting the tissue and keeping its biological information intact. Inside the device, beads create a water-oil emulsion that is then eliminated, removing all inflammatory factors and leaving the adipose cells biologically activated. The resulting material is then injected where needed, allowing the pericytes to detach and establish themselves in the tissue, becoming active mesenchymal stem cells. Anti-Aging Effects In the aesthetic context, Lipogems® works by enhancing microcirculation, counteracting one of the main causes of skin aging. Once grafted, pericytes transform into mesenchymal stem cells that act as "Medicinal Signaling Cells," secreting substances that stimulate the body's self-repair. These signals regulate the immune system, reduce chronic inflammation, and stimulate other cells to regenerate tissues. The immediate effect is visibly improved skin, thanks to the immunomodulatory action that reduces inflammation. Complete results manifest over nine months. Practical Applications Lipogems® can be a partial alternative to surgical lifting, as it improves skin elasticity. However, for significant age-related sagging, it might need to be combined with traditional cosmetic surgery, with the advantage of healthier tissues and faster recovery. The treatment is suitable for all ages, even as prevention, and has no contraindications for conditions such as vitiligo or psoriasis. It can be performed even in summer or sunny environments, as it increases the skin's resistance to the sun. Although a single treatment may be sufficient for life, many patients prefer to repeat it after about four years to maintain optimal results. Source: Vanity Fair Italia, 21. August 2024

Skin longevity means protecting the skin from premature aging and maintaining healthy skin at any age. Image Regenerative Clinic experts provide guidance against sun spots and premature sun-induced aging. Here are recommendations from Dr. Caterina Bristot, a leading expert in both acne treatment and laser procedures for dyschromia, hyperpigmentation, and wrinkles, and Dr. Paolo Salentina, who specializes in innovative aesthetic medicine injection procedures. Sun spots and premature aging wrinkles: what to do? The only way to prevent them is to protect the skin from sun exposure. Always. This is especially important during periods when the desire for perfect tanning often leads to mistakes. Image experts are unanimous about using high SPF sunscreens and physical barriers. Proper protection Direct sun exposure to the face should be avoided. While this goes against popular trends, it's the only genuine way to prevent UV-related damage. Protection should be very high, preferably total coverage. 'I always recommend using physical barriers as well,' Dr. Bristot emphasizes. 'A wide-brimmed hat that shades the neck and décolletage, areas often susceptible to sun spots and texture changes due to improper exposure.' Treatments to prepare skin for tanning 'A series of weekly biorevitalization treatments in the month before departure is highly recommended to ensure greater skin hydration and consequently a more aesthetic and, most importantly, safer tan,' recommends Dr. Salentina. Post-vacation treatment planning Biorevitalization. This should be the first treatment after vacation: it rehydrates the skin from within following exposure to light, sun, wind, salt water effects, and dietary stress common during holidays. The revitalizing complex can be customized with amino acids and polynucleotides for enhanced efficacy, supporting skin renewal by stimulating cellular turnover and fibroblast production of collagen and elastin. Intense Pulsed Light for skin rejuvenation. Another highly effective treatment for addressing sun-induced skin texture changes and discoloration, particularly effective against blue capillaries that often appear after the summer season. Lightening peels and PRX T33 peel. These treatments can be performed in conjunction with other methodologies.

Sun exposure isn't the only factor in skin aging. Scientific studies have demonstrated that facial skin exposed to light from electronic devices such as computers, smartphones, tablets, TVs, and LED lighting ages prematurely. This is a slow and progressive skin aging process that compounds with other risk factors like age, direct sun exposure, alcohol and smoking habits, and atmospheric pollution. How Does Light Cause Skin Aging? At the beach, in the mountains, in the city, and now in the office, our skin is one of the primary targets of oxidative stress caused by exposure to solar rays and electronic device light. The connection between skin aging and oxidative stress is scientifically well-documented. Specifically, cutaneous aging associated with photoaging - light exposure - combined with solar exposure contributes to increasing epigenetic factors, which are environmental influences capable of modifying our cellular DNA. Electronic device and LED light affects the dermis by overheating it, promoting dehydration and collagen fiber deterioration. Over time, the combination of various factors, including age, cigarette smoke, excessive alcohol consumption, and time spent in front of computers and smartphones, contributes to altering our skin functions by modifying the expression of small gene portions (SNPs) present in DNA. This leads to signs of premature skin aging in both males and females, without distinction. Face, Eyes and Dark Circles: Lipogems Treatment Among the first signs of photoaging damage are dark circles and wrinkles around the eyes, as well as loss of facial skin tone. These signs of premature aging can appear even in young individuals. Modern aesthetic medicine and surgery can help correct aging signs, restore facial volumes, and address dark circles that weigh down the eyes and wrinkles around them. The Lipogems treatment represents a significant advancement, as it utilizes the regenerative capabilities of mesenchymal stem cells derived from microfragmented adipose tissue. Unlike traditional lipofilling, Lipogems is an advanced regenerative technique that harnesses the anti-inflammatory and regenerative properties of stem cells present in adipose tissue. The microfragmentation process activates mesenchymal stem cells, enabling them to exert their regenerative action over an extended period. This patented technology maintains adipose tissue integrity, preserving its vascular structure and extracellular matrix, fundamental elements for treatment efficacy.

Understanding cellular aging mechanisms has led to insights into how environment, habits, and lifestyle help slow aging, followed by the development of new drugs targeting specific mechanisms that can decelerate cellular aging, and ultimately to discovering truly effective therapies to halt and slow tissue aging. We discuss this with Professor Carlo Tremolada, Researcher and Director of Image Regenerative Clinic. Supplements and Off-label Medications Supplements that increase NAD (nicotinamide adenine dinucleotide) levels are primary candidates for anti-aging therapies. NAD is crucial for cellular metabolism and longevity, with studies dating back to 1997 when David Sinclair, professor of genetics at Harvard Medical School, discovered that NAD can help regulate a family of proteins called sirtuins, which improve epigenetic health and increase longevity in yeast. This led to interest in resveratrol, a polyphenol found in red wine and used in many supplements, to activate sirtuins. A recent study (Cell Metabolism, 2024) examined promising supplements and off-label medications for slowing aging, including Metformin (primarily used for type 2 diabetes), NAD precursors, Glucagon-like peptide-1 (GLP-1) receptor antagonists, TORC1 inhibitors involved in growth and aging, Spermidine, Senolytics, Probiotics, and Anti-inflammatories. However, their effectiveness on aging and longevity remains a subject of debate in the scientific community. Off-label medications and supplements remain controversial, with ongoing discussions about their efficacy. Cellular Reprogramming Caloric Restriction The effects of caloric restriction on longevity (in laboratory subjects) have been discussed since the 1990s, but it wasn't until 2007 that a major multi-year clinical study called the Calerie Study analyzed the effects of caloric restriction in humans. Recent findings demonstrate that subjects on lower-calorie diets showed reduced inflammation and increased production of immune system T-cells and energy-producing mitochondria. Subsequently, studies on intermittent fasting or time-restricted feeding in mice suggest that such routines could suppress genes involved in inflammation and improve protein production, even at advanced ages. Infiltrative Therapies with Mesenchymal Stem Cells Distinct from umbilical cord or bone marrow stem cell therapies still under study and debate, infiltrative therapies with mesenchymal stem cells are already part of clinical practice for treating various conditions. Among these, the Lipogems regenerative system, patented by Professor Carlo Tremolada, is widely used worldwide by physicians for treating cellular aging and chronic conditions like osteoarthritis. Lipogems is a minimally invasive regenerative procedure that utilizes autologous adipose tissue, rich in mesenchymal stem cells and growth factors, to promote tissue regeneration. The procedure maintains the intact perivascular niche of adipose tissue, ensuring the survival and efficacy of mesenchymal stem cells in the regenerative process.