The Science
Behind Lipogems®

In the medical world, we are witnessing a silent yet powerful revolution: the transition from a “repair-oriented” to a “regeneration-focused” approach. We are no longer satisfied with masking symptoms or replacing what has been damaged — we seek to awaken the body’s innate ability to heal itself. Within this new paradigm, regenerative medicine stands out as a true game changer, especially in treating joint and musculoskeletal disorders that affect millions of people worldwide. At Image Regenerative Clinic , we have been pioneers in this field, developing the Lipogems® methodology thanks to the intuition and research of Professor Carlo Tremolada . However, for those new to this world, confusion often arises. We hear about PRP , stem cells , Lipogems® , but what are the differences? And more importantly, which is the most suitable option? Let’s clarify this by analyzing two of the most discussed regenerative treatments: PRP and Lipogems® . What Is Regenerative Medicine? Before diving into specifics, it’s essential to understand the core concept. Regenerative medicine is not a miraculous cure, but a biological and intelligent approach that leverages the body’s own self-healing mechanisms. Its goal is simple yet ambitious: to use the patient’s own biological resources (blood or adipose tissue) to repair, rebuild, or regenerate tissues damaged by aging, trauma, or chronic diseases such as osteoarthritis. This minimally invasive approach represents a valid alternative to traditional pharmacological treatments or, in many cases, to prosthetic surgery. PRP: Principles and Applications PRP , short for Platelet-Rich Plasma , is one of the most well-known regenerative techniques. The procedure is relatively simple: a small amount of blood is drawn from the patient, then centrifuged to separate its components and concentrate the platelets. The resulting plasma, rich in growth factors, is then injected into the joint or damaged tissue. These growth factors act as powerful messengers, sending biochemical signals to surrounding cells to initiate an anti-inflammatory response and trigger tissue repair. PRP is commonly used to treat tendinopathies, muscle injuries, and early stages of osteoarthritis , where it helps reduce pain and improve functionality. However, it is important to note that PRP mainly provides signaling molecules to stimulate repair, but its effect is typically short-lived . The Lipogems® Method: How It Works Lipogems® represents a major advancement in regenerative medicine, a globally patented system developed by Professor Carlo Tremolada. Unlike PRP, which originates from blood, Lipogems® harnesses the regenerative potential of adipose (fat) tissue , an extraordinarily rich biological resource. The procedure, performed in a sterile environment and on an outpatient basis, involves just a few steps: Harvesting: a small and painless lipoaspiration under local anesthesia, usually from the abdomen or flanks. Processing: the collected fat is inserted into the Lipogems® device , a closed sterile system that gently microfragments the tissue and washes it with saline solution, removing inflammatory and oily residues while preserving the regenerative microenvironment. Injection: the resulting microfragmented and purified fat tissue is then injected precisely into the damaged area under ultrasound guidance. The Lipogems® tissue contains not only growth factors , but also a complete biological matrix : mesenchymal stem cells (MSC) , pericytes , and stromal vascular components that act as natural “healers,” orchestrating a profound and lasting regeneration process. PRP vs. Lipogems®: Advantages and Limitations While both treatments are valid regenerative options, they act on different biological levels and are suited for different clinical scenarios. In simple terms, PRP is a “stimulator” , whereas Lipogems® is a true “regenerator.” Characteristic PRP (Platelet-Rich Plasma) Lipogems® Biological Source Patient’s blood Patient’s adipose tissue Active Component Platelet growth factors Mesenchymal stem cells, pericytes, and stromal matrix Mechanism of Action Cellular stimulation and signaling Complete regenerative process (provides both “builders” and “materials”) Effect Duration Temporary (months) Long-lasting (up to 3–5 years) Main Indications Tendinopathies, mild osteoarthritis Moderate to severe osteoarthritis, cartilage lesions, chronic pain Procedure Type Blood draw and centrifugation Mini-lipoaspiration and same-day tissue processing Lipogems® is considered one of the most advanced next-generation joint injections , particularly effective for damaged cartilage , where simple stimulation is insufficient. In some regions, mesenchymal cell injections are even recognized by national health systems for specific pathologies, confirming their clinical validity. Clinical Cases and Real Experiences The efficacy of Lipogems® is supported by over 175 scientific publications and the experience of thousands of patients . In the sports field, it has been awarded “Best New Technology in Sports Medicine” and is used by elite athletes from Serie A, NBA, and NFL to accelerate recovery and protect joint health. But its benefits go far beyond sports. Consider a 60-year-old man with knee osteoarthritis, chronic pain, and limited mobility, his only remaining option seemed to be a prosthesis. After years of ineffective conservative therapies, he underwent a Lipogems® treatment. Just a few months later, his pain had dramatically decreased, his joint function improved, and he was able to walk and resume normal activities without limitations. This is not an exception, but a powerful example of the regenerative potential within each of us . Final Thoughts and Future Perspectives in Regenerative Medicine The choice between PRP and Lipogems® is not about which is “better” in absolute terms, but which is most appropriate for the specific clinical condition, degree of degeneration, and patient goals. While PRP remains a valuable option for mild inflammatory and degenerative conditions, Lipogems® stands out as the treatment of choice for more significant tissue damage, offering deep regeneration and long-lasting results . The future of orthopedics, and medicine in general, is already taking shape: less invasive, more biological, and deeply personalized . In this landscape, technologies like Lipogems® , which transform a natural body resource into a powerful healing tool, are no longer a promise — they are a solid clinical reality .

This is why we offer aesthetic and regenerative medicine programs that integrate the most advanced technologies with a profound understanding of skin biology. Among the various methodologies, thermotherapy in Milan, offered by Istituto Image, represents one of the most effective and versatile solutions for those who wish to naturally and lastingly improve the appearance of their skin. This treatment, based on the therapeutic use of heat, stimulates the body’s internal regenerative mechanisms, delivering visible results without being invasive. Thermotherapy: What Is It? Principles and Applications Thermotherapy is a therapeutic method that exploits the biological effects of heat to treat a wide range of skin concerns and conditions. At our clinic, we use an advanced form of thermotherapy known as diathermy , a cutting-edge treatment that employs electromagnetic energy to generate heat directly within the tissues (endogenous heat). This principle sets it apart from traditional techniques that apply heat externally. The energy is delivered through specific handpieces that operate in two complementary modes, allowing for deep, targeted action. The choice of mode depends on the treatment goals and the nature of the tissue involved. Resistive Mode : Ideal for acting on high-resistance tissues such as adipose tissue, bones, tendons, and cartilage. The non-insulated electrode concentrates heat deep within the tissue, making it effective for treating fat deposits as well as for rehabilitative applications. Capacitive Mode : The insulated electrode allows heat to focus on more superficial areas, primarily targeting soft tissues such as the dermis, muscles, and vascular and lymphatic systems. This is the preferred choice for improving skin quality and muscle tone. During treatment, our therapists precisely follow the Langer’s lines —the skin’s natural tension lines—to maximize effectiveness while respecting skin physiology. The Benefits of Thermotherapy in Aesthetic Medicine Diathermy is a cornerstone of our face and body rejuvenation programs, thanks to its ability to trigger a virtuous biological response. Controlled, deep heat acts as a powerful biostimulant, providing progressive and concrete benefits. Its main advantage is the direct stimulation of fibroblasts—the cells responsible for producing collagen and elastin. This translates into visible improvements in skin tone, firmness, and elasticity. From the very first session, patients may notice a subtle lifting effect due to the immediate contraction of existing collagen fibers. Applications include: Face : softens wrinkles, redefines contours, and combats skin laxity. Body : an excellent ally against cellulite, fluid retention, and swelling—particularly effective on legs, abdomen, and arms. The thermal effect also enhances oxygenation and microcirculation, promoting fluid and toxin drainage, while leaving the skin healthier and more radiant. How Does Thermotherapy Work for Muscle or Cervical Contractures? Beyond its well-known aesthetic benefits, diathermy also offers significant therapeutic effects, especially in the treatment of musculoskeletal pain. Thanks to its analgesic and anti-inflammatory properties, it is highly effective for those suffering from contractures, muscle tension, and localized pain. The endogenous heat generated by diathermy works on several levels: Enhances vascularization : Improves blood and oxygen supply to inflamed tissues, accelerating healing and reducing inflammation. Relaxes muscles : Helps release tension and contractures, reducing stiffness and improving mobility. Acts on nerve endings : Produces a sedative effect on pain, providing progressive and lasting relief without the use of medication. This makes it particularly suitable for conditions such as neck pain, lower back pain, sciatica, tendinitis, and joint trauma, supporting the functional recovery of tissues. Indications and Contraindications of Thermotherapy Diathermy is a safe, versatile treatment, but like any medical procedure, it has specific indications and contraindications, carefully assessed during the initial consultation. Transparency is a core value, ensuring every patient begins their therapeutic journey with clarity and trust. Main Treatment Areas Main Contraindications Wrinkles and Skin Laxity – Face, Neck, Décolleté, Arms Pregnancy Cellulite and Water Retention – Legs, Buttocks, Abdomen Pacemakers Dull, Sagging Skin – Face and Body Severe cardiac or vascular conditions Contractures and Muscle Pain – Back, Neck, Shoulders, Limbs Active skin infections or lesions Swelling and Heaviness – Legs and Ankles Ongoing tumors or oncological conditions Tips to Maximize Thermotherapy Results Diathermy delivers excellent results, but its effectiveness reaches its peak within a personalized, integrated protocol. At Istituto Image, every treatment is part of a holistic pathway toward patient well-being. For this reason, diathermy is often combined with other methods to create powerful synergies. For instance: In our personalized medical weight-loss program , diathermy is essential to tone tissues that may lose elasticity during weight reduction, ensuring a firmer and more defined silhouette. To combat cellulite and localized fat, diathermy can be preceded by Shockwave Therapy , which prepares tissues for enhanced receptivity, and followed by draining or lipolytic mesotherapy sessions for targeted action. Technologies such as Coolwaves® can work in synergy for body contouring, while manual treatments like lymphatic drainage or cupping therapy enhance detox and draining effects, helping eliminate excess fluids. To maintain long-term benefits, we recommend following our specialists’ advice, staying well-hydrated, and adopting a healthy, active lifestyle. Thermotherapy at Istituto Image: Our Specialized Offering At Istituto Image, every treatment journey begins with a personalized regenerative analysis —an in-depth clinical evaluation performed by our medical team. This allows us to fully understand each patient’s unique needs and build a tailor-made protocol, where diathermy integrates with other cutting-edge technologies. Our approach is both scientific and holistic: we don’t just treat aesthetic concerns, but work to restore the biological balance of tissues. The expertise of our team, guided by the scientific vision of Professor Carlo Tremolada , along with state-of-the-art equipment, guarantees safety, comfort, and real results. Choosing diathermy treatment at our institute means placing your trust in an excellence of regenerative medicine—for well-being that can be both seen and felt. Contact Istituto Image today and book your regenerative analysis. Let’s begin your journey to well-being together! FAQ What is thermotherapy used for? Thermotherapy stimulates the body’s regenerative processes through heat. In aesthetic medicine, it is used to tone the skin, reduce wrinkles and cellulite, and improve circulation. In therapeutic applications, it relieves muscle pain, contractures, and inflammation. What is heat therapy used for? Heat therapy generates a controlled increase in tissue temperature to achieve specific benefits. It enhances blood flow, promotes oxygenation and toxin elimination, stimulates collagen production for firmer skin, and relaxes contracted muscle fibers with an analgesic effect. What kinds of pain does heat relieve? Heat is especially effective for relieving muscle and joint pain. It is recommended for contractures, neck tension, lower back pain, menstrual pain, and joint stiffness. It relaxes muscles, improves circulation, and reduces pain perception. How much does thermotherapy cost? The cost of a thermotherapy (diathermy) program varies, as it depends on the personalized treatment plan established during consultation. Factors include the number of sessions required, the size of the treatment areas, and any combination with other synergistic technologies. To receive a detailed, tailored quote, we recommend booking a consultation with our specialists.

At Istituto Image, we see aesthetic medicine as a journey towards harmony and wellbeing, where every procedure is designed to enhance the uniqueness of the face without altering its essence. Among our cutting-edge solutions, we offer blepharoplasty in Milan with Lipogems, ideal for those wishing to correct imperfections such as drooping eyelids, combining surgical excellence with the most advanced regenerative medicine techniques. Our goal is to restore freshness and vitality to the gaze, with natural, long-lasting results and an optimized recovery. Drooping Eyelids: What Are They? Causes and Symptoms Drooping eyelids, technically known as eyelid ptosis, occur when the upper eyelid lowers, partially or fully covering the pupil. This condition can give the face a permanently tired, sad, or aged appearance, even when one feels full of energy. The main causes are linked to the natural aging process. Over time, the skin loses elasticity and tone due to reduced collagen production, and the muscles that support the eyelid tend to weaken. Other factors can also contribute or accelerate this process: Genetic factors: A family predisposition may affect the structure and firmness of the periocular area. Lifestyle: Excessive sun exposure without protection, smoking, and unhealthy habits can accelerate skin aging. Traumatic or pathological causes: In rarer cases, ptosis may result from trauma or specific medical conditions. Symptoms are not just aesthetic. Many people feel heaviness in the eyes and, in more severe cases, experience an actual reduction in the upper visual field, interfering with daily activities such as reading or driving. When Should You Consider Surgery for Drooping Eyelids? The decision to undergo surgery for drooping eyelids is personal and arises when the condition starts to negatively affect quality of life, both functionally and psychologically. It is time to consider correction when: The visual field is limited: If you must tilt your head back or raise your eyebrows to see properly, surgery becomes functional, improving vision. Appearance no longer reflects how you feel: When the mirror shows a tired, aged image that doesn’t match your inner vitality, correction can restore confidence and self-esteem. Psychological discomfort becomes significant: Feeling uneasy when interacting with others or avoiding eye contact signals a deeper impact on emotional wellbeing. Non-surgical remedies are no longer enough: When creams and non-invasive aesthetic treatments fail to achieve the desired effect, surgery becomes the most effective and lasting solution. Blepharoplasty: Plastic Surgery for Drooping Eyelids Blepharoplasty is the gold-standard surgical procedure for correcting drooping eyelids—a refined surgery that rejuvenates the gaze with natural, harmonious results. The operation consists of the precise removal of excess skin and, if necessary, herniated fat forming under-eye bags, through incisions hidden in the natural eyelid folds, leaving scars virtually invisible. At Istituto Image, we have elevated this surgery to the next level by creating Regenerative Blepharoplasty . Under the guidance of Professor Carlo Tremolada, we integrate surgical precision with the innovative Lipogems® technology. During the same session, a small amount of the patient’s adipose tissue is harvested, processed with the patented Lipogems® system, and injected into the periocular area. This regenerative graft brings extraordinary benefits: Improves the quality and elasticity of the thin eyelid skin. Restores natural volume lost with aging, effectively addressing dark circles and tear troughs. Thanks to powerful anti-inflammatory properties, reduces swelling and speeds up healing. For selected cases, the pathway may be complemented with laser therapy to further enhance skin texture and reduce fine wrinkles, achieving a comprehensive rejuvenation of the gaze. What to Expect During Post-Surgery Recovery Recovery after blepharoplasty is usually well tolerated and quick. In the first 48–72 hours, mild swelling and bruising are normal and can be managed with cold compresses. Thanks to the regenerative Lipogems® approach, our patients benefit from accelerated healing, with significantly reduced swelling and discomfort. Stitches are typically removed after 5–7 days. Returning to social activities is usually possible after 10–14 days, while intense physical activity should wait around one month. The final results settle and become fully visible after a few months, revealing a more open, refreshed, and rested gaze. Useful Tips to Maintain Surgical Results Blepharoplasty provides very long-lasting results, often lasting 10–15 years. However, the natural aging process continues. To preserve the freshness of your gaze over time, we recommend adopting some good habits: Sun Protection: Daily use of a high-SPF sunscreen around the eye area is the most important step to prevent photoaging. Proper Skincare: Using specific eye-contour products rich in antioxidants, peptides, and hyaluronic acid helps keep skin hydrated and elastic. Healthy Lifestyle: Avoiding smoking, following a balanced diet, and ensuring proper sleep are crucial factors for skin health. Maintenance Treatments: Non-invasive procedures such as biorevitalization, light peels, or radiofrequency can be scheduled to maintain skin quality and extend results. Why Choose istitutoimage.it for Your Aesthetic Medicine Procedure Choosing Istituto Image for the correction of drooping eyelids means relying on a center of excellence that combines medical expertise, technological innovation, and a philosophy centered on natural results. Our offer stands out for: A Unique Regenerative Approach: We are pioneers in integrating blepharoplasty with Lipogems® technology, a method that not only corrects but regenerates tissues, ensuring superior results and faster recovery. Maximum Surgical Expertise: Our team, led by Professor Carlo Tremolada, holds dual specialization in plastic and maxillofacial surgery, ensuring deep anatomical knowledge of the face for safe and precise procedures. Natural, Personalized Results: Each procedure is tailor-made for the patient, with the goal of refreshing the gaze while preserving expression and identity. Comprehensive Care: From the first consultation to post-operative follow-up, our dedicated team provides care, attention, and support at every stage. Drooping eyelids may make you look tired, but they do not define who you are. At Istituto Image, we don’t just correct an imperfection: with our exclusive Regenerative Blepharoplasty with Lipogems® , we regenerate tissues to restore a fresh, open gaze in perfect harmony with your face. It’s time to see yourself again as you truly feel. Book a consultation with our surgeons and discover how we can rejuvenate your eyes with natural, long-lasting results. FAQ How can you lift a drooping eyelid? For an effective and lasting lift, surgical blepharoplasty is the most recommended solution. For mild cases, non-surgical alternatives such as radiofrequency, fractional lasers, or thread lifts can offer temporary improvement. How many years younger can blepharoplasty make you look? It is not possible to define an exact number of years, but blepharoplasty significantly rejuvenates the gaze. It eliminates a tired, heavy look, giving the face a fresher, more rested, and more vibrant expression that can make you appear several years younger overall. Is blepharoplasty dangerous? Like any surgery, blepharoplasty carries risks, but when performed by a specialized, qualified plastic surgeon in a suitable facility, it is considered extremely safe with a very low complication rate. What are the non-surgical remedies for drooping eyelids? For mild eyelid laxity, non-surgical remedies include microneedle radiofrequency, laser resurfacing, micro-focused ultrasound, and thread lifts. These methods stimulate collagen production and provide a moderate, temporary lifting effect. What is the best treatment for drooping eyelids? The “best” treatment depends on the degree of ptosis. For mild to moderate sagging, non-surgical options may provide good results. For more severe cases with significant excess skin, blepharoplasty remains the gold standard, offering the most effective, complete, and long-lasting outcome. What can you do instead of blepharoplasty? As an alternative to surgical blepharoplasty, early sagging can be addressed with treatments like fractional laser, microneedle radiofrequency, or thread lifts. These approaches can improve skin firmness and provide a mild lifting effect, but cannot replace the effectiveness of surgery in cases of significant skin excess.

At Istituto Image, we approach personal well-being with a method that integrates scientific innovation and a deep understanding of the body’s biological mechanisms. For this reason, we offer cutting-edge solutions for painful and disabling conditions such as Morton’s Neuroma. Our goal is not only to relieve symptoms but to act on the root cause of inflammation through advanced regenerative therapies, such as the Lipogems technology, to provide effective and lasting relief and improve quality of life. What is Morton’s Neuroma? Morton’s Neuroma, despite its name, is not a tumor or neoplasm, but a benign degenerative condition affecting one of the interdigital nerves of the foot. It is a perineural fibrosis, meaning a thickening of the connective tissue surrounding the nerve, caused by chronic irritation or mechanical compression. This condition most commonly develops in the space between the third and fourth toes, an area anatomically more prone to stress and microtrauma. The increase in fibrous tissue volume compresses the nerve, triggering painful and bothersome symptoms that can become disabling in daily activities. The sensation is often described as having a “pebble in the shoe,” a persistent discomfort that prevents normal walking. Common Symptoms of Morton’s Neuroma in the Foot Nerves The symptoms of Morton’s Neuroma are very characteristic and tend to worsen with tight footwear or physical activity, then ease with rest and by removing the shoes. Recognizing them is the first step toward a correct diagnosis. The most common signs include: Sharp, burning pain: Mainly localized in the forefoot, at the base of the toes. Foreign body sensation: The feeling of having a pebble, a bead, or a fold in the sock under the foot. Electric shocks or tingling: Pain and numbness radiating towards the affected toes. Toe cramps: The sensation of toes “overlapping” or sudden cramps. Immediate relief when removing shoes: A typical and almost instinctive gesture is taking off footwear and massaging the area to find relief. Main Causes of Morton’s Neuroma Morton’s Neuroma is a condition caused by mechanical overload. Inflammation and the subsequent nerve thickening are the body’s response to compression or repeated stress over time. Understanding the causes is essential to set an effective prevention and treatment strategy. The pain under the foot at the base of the toes is the main warning sign, which can appear as sudden sharp stabs to the toes, sometimes radiating into more generalized discomfort that also affects the big toe area due to altered walking mechanics. The main risk factors include: Risk Factor Description and Impact on the Nerve Inadequate Footwear The most common cause. Prolonged use of high heels, narrow-toed, or ill-fitting shoes forces the forefoot into an unnatural position, increasing compression and pressure on the interdigital nerves. Biomechanical Dysfunctions Alterations in posture or foot morphology (e.g., flatfoot, high-arched foot, hallux valgus, hammer toes) change weight distribution on the forefoot. This imbalance favors irritation and inflammation of the nerve. High-Impact Activities Sports such as running and dancing, or jobs requiring standing for many hours, cause repeated microtrauma to the forefoot, continuously stressing the area and nerves. Direct Trauma A single injury or direct blow to the foot can damage the nerve and trigger the acute inflammatory process that leads to neuroma formation. Diagnosis: How to Recognize Morton’s Neuroma An accurate diagnosis is essential to distinguish Morton’s Neuroma from other foot conditions with similar symptoms (such as stress fractures, bursitis, or arthritis). The diagnostic pathway is based on two key steps: Clinical Examination: The specialist collects the patient’s history, analyzing the type of pain and habits (work, sports, footwear). During the visit, they perform targeted palpation of the intermetatarsal area. A specific test, the “Mulder’s sign,” consists of lateral compression of the forefoot: if this maneuver elicits a painful “click,” the diagnosis of Morton’s Neuroma is highly likely. Imaging Diagnostics: Ultrasound is the first-choice test, as it accurately shows the fibrous thickening of the nerve and allows measurement of its size. In doubtful cases, or to exclude other pathologies, MRI may be requested, providing a more detailed view of the soft tissues and bone structures of the foot. Medical Treatments for Walking with Morton’s Neuroma The aim of treatment is to reduce nerve compression, alleviate inflammation, and resolve pain. The approach is gradual, starting with the most conservative solutions and moving toward more innovative options. Conservative Therapies: The first step includes the use of custom orthotics to offload the metatarsal area, the choice of comfortable, wide-toe footwear, and cycles of physiotherapy (physical therapies such as tecar therapy or laser and stretching). Corticosteroid Injections: If pain persists, cortisone injections can reduce inflammation, providing relief that is often temporary. Regenerative Medicine with Lipogems®: At Istituto Image, we offer a regenerative approach as an alternative to traditional therapies. Treatment with Lipogems® consists of infiltrating micro-fragmented adipose tissue harvested from the patient. This tissue is rich in mesenchymal cells with strong anti-inflammatory and regenerative properties. The infiltration creates a natural cushion that protects the nerve from compression, reduces inflammation in a lasting way, and stimulates tissue repair processes. Surgery: If other therapies fail, surgical intervention is performed, consisting of removing the neuroma (neurectomy). Although definitive, the surgery results in loss of sensitivity in the affected area. Prevention and At-Home Care Strategies Prevention is the best cure for Morton’s Neuroma. Adopting a few simple habits can drastically reduce the risk of developing this bothersome condition or worsening its symptoms: Choose the Right Shoes: Opt for comfortable footwear with a wide toe box that does not compress the toes and a heel no higher than 3–4 cm. Alternate different shoes throughout the week. Use Orthotics: If foot support is incorrect, a custom orthotic can make the difference by distributing weight evenly. Manage Acute Phases: In case of pain, apply ice to the affected area for 15–20 minutes and keep the foot at rest. Stretching Exercises: Regularly stretching the calf and sole muscles can help reduce tension on the forefoot. 👉 Contact our specialists and book a consultation to define the most effective treatment pathway for you! FAQ Why does Morton’s Neuroma form? Morton’s Neuroma forms due to chronic compression and irritation of an interdigital nerve in the foot. The main causes are tight or high-heeled shoes, alterations in foot shape (e.g., hallux valgus), or repeated microtraumas from certain sports or work activities. How can Morton’s Neuroma inflammation be reduced? It can start with conservative remedies such as rest, ice application, and comfortable footwear. Medically, corticosteroid injections can reduce inflammation. An advanced and natural alternative is regenerative therapy with Lipogems®, which has a powerful anti-inflammatory and regenerative effect. Can Morton’s Neuroma heal on its own? It is very unlikely for Morton’s Neuroma, being a fibrotic degeneration of nerve tissue, to heal spontaneously. However, symptoms may regress and be controlled by adopting proper conservative measures (adequate shoes, orthotics) and avoiding triggers. How do I know if I have Morton’s Neuroma? Typical symptoms are burning pain in the forefoot, the sensation of having a “pebble in the shoe,” and tingling in the toes, which worsen with tight shoes. For a certain diagnosis, a specialist consultation is essential, including clinical examination (with Mulder’s Test) and ultrasound. What is the treatment for Morton’s Neuroma? The treatment follows a gradual approach: it starts with conservative methods (orthotics, proper footwear, physiotherapy). If these are insufficient, infiltrative therapies (cortisone or regenerative medicine such as Lipogems®) are considered. Surgical removal of the neuroma is reserved for cases that do not respond to other therapies.