The Science
Behind Lipogems®

At Istituto Image, we see aesthetic medicine as a journey towards harmony and wellbeing, where every procedure is designed to enhance the uniqueness of the face without altering its essence. Among our cutting-edge solutions, we offer blepharoplasty in Milan with Lipogems, ideal for those wishing to correct imperfections such as drooping eyelids, combining surgical excellence with the most advanced regenerative medicine techniques. Our goal is to restore freshness and vitality to the gaze, with natural, long-lasting results and an optimized recovery. Drooping Eyelids: What Are They? Causes and Symptoms Drooping eyelids, technically known as eyelid ptosis, occur when the upper eyelid lowers, partially or fully covering the pupil. This condition can give the face a permanently tired, sad, or aged appearance, even when one feels full of energy. The main causes are linked to the natural aging process. Over time, the skin loses elasticity and tone due to reduced collagen production, and the muscles that support the eyelid tend to weaken. Other factors can also contribute or accelerate this process: Genetic factors: A family predisposition may affect the structure and firmness of the periocular area. Lifestyle: Excessive sun exposure without protection, smoking, and unhealthy habits can accelerate skin aging. Traumatic or pathological causes: In rarer cases, ptosis may result from trauma or specific medical conditions. Symptoms are not just aesthetic. Many people feel heaviness in the eyes and, in more severe cases, experience an actual reduction in the upper visual field, interfering with daily activities such as reading or driving. When Should You Consider Surgery for Drooping Eyelids? The decision to undergo surgery for drooping eyelids is personal and arises when the condition starts to negatively affect quality of life, both functionally and psychologically. It is time to consider correction when: The visual field is limited: If you must tilt your head back or raise your eyebrows to see properly, surgery becomes functional, improving vision. Appearance no longer reflects how you feel: When the mirror shows a tired, aged image that doesn’t match your inner vitality, correction can restore confidence and self-esteem. Psychological discomfort becomes significant: Feeling uneasy when interacting with others or avoiding eye contact signals a deeper impact on emotional wellbeing. Non-surgical remedies are no longer enough: When creams and non-invasive aesthetic treatments fail to achieve the desired effect, surgery becomes the most effective and lasting solution. Blepharoplasty: Plastic Surgery for Drooping Eyelids Blepharoplasty is the gold-standard surgical procedure for correcting drooping eyelids—a refined surgery that rejuvenates the gaze with natural, harmonious results. The operation consists of the precise removal of excess skin and, if necessary, herniated fat forming under-eye bags, through incisions hidden in the natural eyelid folds, leaving scars virtually invisible. At Istituto Image, we have elevated this surgery to the next level by creating Regenerative Blepharoplasty . Under the guidance of Professor Carlo Tremolada, we integrate surgical precision with the innovative Lipogems® technology. During the same session, a small amount of the patient’s adipose tissue is harvested, processed with the patented Lipogems® system, and injected into the periocular area. This regenerative graft brings extraordinary benefits: Improves the quality and elasticity of the thin eyelid skin. Restores natural volume lost with aging, effectively addressing dark circles and tear troughs. Thanks to powerful anti-inflammatory properties, reduces swelling and speeds up healing. For selected cases, the pathway may be complemented with laser therapy to further enhance skin texture and reduce fine wrinkles, achieving a comprehensive rejuvenation of the gaze. What to Expect During Post-Surgery Recovery Recovery after blepharoplasty is usually well tolerated and quick. In the first 48–72 hours, mild swelling and bruising are normal and can be managed with cold compresses. Thanks to the regenerative Lipogems® approach, our patients benefit from accelerated healing, with significantly reduced swelling and discomfort. Stitches are typically removed after 5–7 days. Returning to social activities is usually possible after 10–14 days, while intense physical activity should wait around one month. The final results settle and become fully visible after a few months, revealing a more open, refreshed, and rested gaze. Useful Tips to Maintain Surgical Results Blepharoplasty provides very long-lasting results, often lasting 10–15 years. However, the natural aging process continues. To preserve the freshness of your gaze over time, we recommend adopting some good habits: Sun Protection: Daily use of a high-SPF sunscreen around the eye area is the most important step to prevent photoaging. Proper Skincare: Using specific eye-contour products rich in antioxidants, peptides, and hyaluronic acid helps keep skin hydrated and elastic. Healthy Lifestyle: Avoiding smoking, following a balanced diet, and ensuring proper sleep are crucial factors for skin health. Maintenance Treatments: Non-invasive procedures such as biorevitalization, light peels, or radiofrequency can be scheduled to maintain skin quality and extend results. Why Choose istitutoimage.it for Your Aesthetic Medicine Procedure Choosing Istituto Image for the correction of drooping eyelids means relying on a center of excellence that combines medical expertise, technological innovation, and a philosophy centered on natural results. Our offer stands out for: A Unique Regenerative Approach: We are pioneers in integrating blepharoplasty with Lipogems® technology, a method that not only corrects but regenerates tissues, ensuring superior results and faster recovery. Maximum Surgical Expertise: Our team, led by Professor Carlo Tremolada, holds dual specialization in plastic and maxillofacial surgery, ensuring deep anatomical knowledge of the face for safe and precise procedures. Natural, Personalized Results: Each procedure is tailor-made for the patient, with the goal of refreshing the gaze while preserving expression and identity. Comprehensive Care: From the first consultation to post-operative follow-up, our dedicated team provides care, attention, and support at every stage. Drooping eyelids may make you look tired, but they do not define who you are. At Istituto Image, we don’t just correct an imperfection: with our exclusive Regenerative Blepharoplasty with Lipogems® , we regenerate tissues to restore a fresh, open gaze in perfect harmony with your face. It’s time to see yourself again as you truly feel. Book a consultation with our surgeons and discover how we can rejuvenate your eyes with natural, long-lasting results. FAQ How can you lift a drooping eyelid? For an effective and lasting lift, surgical blepharoplasty is the most recommended solution. For mild cases, non-surgical alternatives such as radiofrequency, fractional lasers, or thread lifts can offer temporary improvement. How many years younger can blepharoplasty make you look? It is not possible to define an exact number of years, but blepharoplasty significantly rejuvenates the gaze. It eliminates a tired, heavy look, giving the face a fresher, more rested, and more vibrant expression that can make you appear several years younger overall. Is blepharoplasty dangerous? Like any surgery, blepharoplasty carries risks, but when performed by a specialized, qualified plastic surgeon in a suitable facility, it is considered extremely safe with a very low complication rate. What are the non-surgical remedies for drooping eyelids? For mild eyelid laxity, non-surgical remedies include microneedle radiofrequency, laser resurfacing, micro-focused ultrasound, and thread lifts. These methods stimulate collagen production and provide a moderate, temporary lifting effect. What is the best treatment for drooping eyelids? The “best” treatment depends on the degree of ptosis. For mild to moderate sagging, non-surgical options may provide good results. For more severe cases with significant excess skin, blepharoplasty remains the gold standard, offering the most effective, complete, and long-lasting outcome. What can you do instead of blepharoplasty? As an alternative to surgical blepharoplasty, early sagging can be addressed with treatments like fractional laser, microneedle radiofrequency, or thread lifts. These approaches can improve skin firmness and provide a mild lifting effect, but cannot replace the effectiveness of surgery in cases of significant skin excess.

At Istituto Image, we approach personal well-being with a method that integrates scientific innovation and a deep understanding of the body’s biological mechanisms. For this reason, we offer cutting-edge solutions for painful and disabling conditions such as Morton’s Neuroma. Our goal is not only to relieve symptoms but to act on the root cause of inflammation through advanced regenerative therapies, such as the Lipogems technology, to provide effective and lasting relief and improve quality of life. What is Morton’s Neuroma? Morton’s Neuroma, despite its name, is not a tumor or neoplasm, but a benign degenerative condition affecting one of the interdigital nerves of the foot. It is a perineural fibrosis, meaning a thickening of the connective tissue surrounding the nerve, caused by chronic irritation or mechanical compression. This condition most commonly develops in the space between the third and fourth toes, an area anatomically more prone to stress and microtrauma. The increase in fibrous tissue volume compresses the nerve, triggering painful and bothersome symptoms that can become disabling in daily activities. The sensation is often described as having a “pebble in the shoe,” a persistent discomfort that prevents normal walking. Common Symptoms of Morton’s Neuroma in the Foot Nerves The symptoms of Morton’s Neuroma are very characteristic and tend to worsen with tight footwear or physical activity, then ease with rest and by removing the shoes. Recognizing them is the first step toward a correct diagnosis. The most common signs include: Sharp, burning pain: Mainly localized in the forefoot, at the base of the toes. Foreign body sensation: The feeling of having a pebble, a bead, or a fold in the sock under the foot. Electric shocks or tingling: Pain and numbness radiating towards the affected toes. Toe cramps: The sensation of toes “overlapping” or sudden cramps. Immediate relief when removing shoes: A typical and almost instinctive gesture is taking off footwear and massaging the area to find relief. Main Causes of Morton’s Neuroma Morton’s Neuroma is a condition caused by mechanical overload. Inflammation and the subsequent nerve thickening are the body’s response to compression or repeated stress over time. Understanding the causes is essential to set an effective prevention and treatment strategy. The pain under the foot at the base of the toes is the main warning sign, which can appear as sudden sharp stabs to the toes, sometimes radiating into more generalized discomfort that also affects the big toe area due to altered walking mechanics. The main risk factors include: Risk Factor Description and Impact on the Nerve Inadequate Footwear The most common cause. Prolonged use of high heels, narrow-toed, or ill-fitting shoes forces the forefoot into an unnatural position, increasing compression and pressure on the interdigital nerves. Biomechanical Dysfunctions Alterations in posture or foot morphology (e.g., flatfoot, high-arched foot, hallux valgus, hammer toes) change weight distribution on the forefoot. This imbalance favors irritation and inflammation of the nerve. High-Impact Activities Sports such as running and dancing, or jobs requiring standing for many hours, cause repeated microtrauma to the forefoot, continuously stressing the area and nerves. Direct Trauma A single injury or direct blow to the foot can damage the nerve and trigger the acute inflammatory process that leads to neuroma formation. Diagnosis: How to Recognize Morton’s Neuroma An accurate diagnosis is essential to distinguish Morton’s Neuroma from other foot conditions with similar symptoms (such as stress fractures, bursitis, or arthritis). The diagnostic pathway is based on two key steps: Clinical Examination: The specialist collects the patient’s history, analyzing the type of pain and habits (work, sports, footwear). During the visit, they perform targeted palpation of the intermetatarsal area. A specific test, the “Mulder’s sign,” consists of lateral compression of the forefoot: if this maneuver elicits a painful “click,” the diagnosis of Morton’s Neuroma is highly likely. Imaging Diagnostics: Ultrasound is the first-choice test, as it accurately shows the fibrous thickening of the nerve and allows measurement of its size. In doubtful cases, or to exclude other pathologies, MRI may be requested, providing a more detailed view of the soft tissues and bone structures of the foot. Medical Treatments for Walking with Morton’s Neuroma The aim of treatment is to reduce nerve compression, alleviate inflammation, and resolve pain. The approach is gradual, starting with the most conservative solutions and moving toward more innovative options. Conservative Therapies: The first step includes the use of custom orthotics to offload the metatarsal area, the choice of comfortable, wide-toe footwear, and cycles of physiotherapy (physical therapies such as tecar therapy or laser and stretching). Corticosteroid Injections: If pain persists, cortisone injections can reduce inflammation, providing relief that is often temporary. Regenerative Medicine with Lipogems®: At Istituto Image, we offer a regenerative approach as an alternative to traditional therapies. Treatment with Lipogems® consists of infiltrating micro-fragmented adipose tissue harvested from the patient. This tissue is rich in mesenchymal cells with strong anti-inflammatory and regenerative properties. The infiltration creates a natural cushion that protects the nerve from compression, reduces inflammation in a lasting way, and stimulates tissue repair processes. Surgery: If other therapies fail, surgical intervention is performed, consisting of removing the neuroma (neurectomy). Although definitive, the surgery results in loss of sensitivity in the affected area. Prevention and At-Home Care Strategies Prevention is the best cure for Morton’s Neuroma. Adopting a few simple habits can drastically reduce the risk of developing this bothersome condition or worsening its symptoms: Choose the Right Shoes: Opt for comfortable footwear with a wide toe box that does not compress the toes and a heel no higher than 3–4 cm. Alternate different shoes throughout the week. Use Orthotics: If foot support is incorrect, a custom orthotic can make the difference by distributing weight evenly. Manage Acute Phases: In case of pain, apply ice to the affected area for 15–20 minutes and keep the foot at rest. Stretching Exercises: Regularly stretching the calf and sole muscles can help reduce tension on the forefoot. 👉 Contact our specialists and book a consultation to define the most effective treatment pathway for you! FAQ Why does Morton’s Neuroma form? Morton’s Neuroma forms due to chronic compression and irritation of an interdigital nerve in the foot. The main causes are tight or high-heeled shoes, alterations in foot shape (e.g., hallux valgus), or repeated microtraumas from certain sports or work activities. How can Morton’s Neuroma inflammation be reduced? It can start with conservative remedies such as rest, ice application, and comfortable footwear. Medically, corticosteroid injections can reduce inflammation. An advanced and natural alternative is regenerative therapy with Lipogems®, which has a powerful anti-inflammatory and regenerative effect. Can Morton’s Neuroma heal on its own? It is very unlikely for Morton’s Neuroma, being a fibrotic degeneration of nerve tissue, to heal spontaneously. However, symptoms may regress and be controlled by adopting proper conservative measures (adequate shoes, orthotics) and avoiding triggers. How do I know if I have Morton’s Neuroma? Typical symptoms are burning pain in the forefoot, the sensation of having a “pebble in the shoe,” and tingling in the toes, which worsen with tight shoes. For a certain diagnosis, a specialist consultation is essential, including clinical examination (with Mulder’s Test) and ultrasound. What is the treatment for Morton’s Neuroma? The treatment follows a gradual approach: it starts with conservative methods (orthotics, proper footwear, physiotherapy). If these are insufficient, infiltrative therapies (cortisone or regenerative medicine such as Lipogems®) are considered. Surgical removal of the neuroma is reserved for cases that do not respond to other therapies.

At Image Regenerative Clinic, we believe that turning 50 marks a stage of renewed awareness and radiance. However, the skin often tells a different story, showing the signs of time more evidently. This is why we offer an approach to aesthetic medicine that goes beyond simply correcting wrinkles: a true journey of deep regeneration. Among the most innovative treatments, we propose Lipogems® for the Face , a solution that stimulates the skin’s natural rejuvenation processes. Our goal is to awaken the biological vitality of the skin through integrated scientific protocols that restore tone, firmness, and radiance for authentic rejuvenation, while respecting the unique harmony of every face. The Importance of Personalized Diagnosis At 50, the skin of the face has complex and highly individual needs. Factors such as genetics, lifestyle, and hormonal changes related to menopause cause a loss of collagen, volume, and hydration in different ways and at different times. For this reason, a “one-size-fits-all” approach is bound to fail. The first essential step is a personalized regenerative analysis . At our Institute, every journey begins with an in-depth medical evaluation that, through advanced diagnostic technologies, maps the skin’s health. We analyze crucial parameters such as dermal thickness, the degree of solar elastosis, volume loss, and the quality of the subcutaneous adipose tissue. This precise diagnosis allows us to create a tailor-made therapeutic plan—a true rejuvenation program that targets what is really needed, ensuring effective and natural results. Non-Invasive Treatments for Facial Rejuvenation To start and maintain a rejuvenation journey over time, there are non-invasive treatments that work by stimulating the skin from within, improving its quality and structure. Type of Biostimulant How It Works Results and Main Indications Advanced Biostimulants (Sculptra® & Radiesse®) Actively stimulate fibroblasts to produce new collagen, triggering a gradual and natural rejuvenation process. The result is visibly denser, firmer skin with long-lasting effects. Ideal for counteracting skin laxity and redefining facial contours. Biostimulating Peel (PRX-T33) Stimulates the dermis in depth without causing the aggressive exfoliation typical of traditional peels. Improves skin texture, brightness, and tone, with the major advantage of having zero downtime. Polynucleotides Regenerate the skin at a cellular level, acting specifically on delicate and hard-to-treat areas. Perfect for the eye contour, they improve elasticity and reduce fine lines without altering or overfilling natural facial volumes. Advanced Technologies for Rejuvenation at 50 For a powerful impact capable of producing significant and visible rejuvenation, an integrated approach combining the most effective technologies of regenerative medicine is essential. Our annual skin regeneration program is built on this synergy. Fractional CO₂ Laser : The gold standard for skin resurfacing. It works by creating micro-columns of heat that stimulate abundant collagen production—ideal for treating deep wrinkles, irregular texture, and scars. Photobiomodulation Therapy (Kleresca®) : A non-invasive technology that uses fluorescent light energy to activate skin repair mechanisms at a cellular level. It increases collagen production by up to 400%, reduces inflammation, and improves conditions such as rosacea, giving skin a healthier and younger appearance. Lipogems® for the Face : Patented by Prof. Carlo Tremolada, this technology is at the heart of our regenerative approach. It harnesses the potential of mesenchymal cells present in one’s own adipose tissue. A small amount of fat is harvested, processed, and re-injected into the face. Lipogems® not only restores lost volume naturally and permanently but also regenerates the skin biologically, improving thickness, color, and quality in a way no other treatment can match. For an overview, we have summarized the main options in a comparative table to help guide the choice of the most suitable pathway. Tips for Maintaining Beautiful Skin Aesthetic medicine treatments deliver extraordinary results, but to maintain them over time, adopting a proper daily routine is essential. A consistent beauty routine is key to firming the skin, preventing sagging, and keeping it visibly more toned and radiant. Skincare is the first fundamental pillar: after 50, the skin needs powerful active ingredients, so it is important to prioritize serums and creams with retinoids for cell renewal, peptides for firmness, vitamin C as a strong antioxidant, and hyaluronic acid for hydration. Equally crucial is daily sun protection : UV rays are the main cause of skin aging, making SPF 50+ indispensable every day, even in winter and in the city. Nutrition and hydration play a vital role: drink at least 1.5–2 liters of water per day and follow a diet rich in antioxidants (berries, leafy greens), healthy fats (salmon, avocado, nuts), and lean proteins that provide the building blocks for collagen production. Finally, lifestyle has a decisive impact: smoking and poor-quality sleep drastically accelerate aging. Getting enough rest and, if possible, avoiding smoking are among the greatest gifts you can give your skin. How to Choose the Right Aesthetic Medicine Clinic Entrusting your face to a professional is an important decision. For a rejuvenation journey at 50, it is crucial to choose a clinic that offers: High Medical Expertise : Ensure treatments are performed by specialist doctors with in-depth knowledge of facial anatomy and the technologies they use. A Personalized Approach : Be wary of “one-size-fits-all” solutions. An excellence-driven clinic, like Image Regenerative Clinic, builds every treatment on a scientific and individual diagnosis. Cutting-Edge Technologies : The presence of advanced, clinically tested technologies (lasers, biostimulants, regenerative therapies) is a clear indicator of quality and safety. A Regenerative Philosophy : Choose a clinic that aims to improve your skin’s long-term health, promoting natural, harmonious results rather than artificial, temporary corrections. At 50, your skin has complex needs that require an excellence-based approach. At Image Regenerative Clinic, we go beyond standard treatments. Through precise diagnosis, we design integrated protocols that combine the most powerful regenerative technologies, from Fractional CO₂ Laser to the groundbreaking Lipogems®. Trust those who place science at the service of your beauty. Contact us for an in-depth medical consultation and discover which of our advanced solutions is best suited for you. FAQ What are the secrets to having a beautiful face at 50? The secrets lie in an integrated approach: a personalized medical diagnosis, a treatment plan combining biostimulation and regenerative technologies (such as lasers and Lipogems®), daily skincare with powerful actives (retinoids, vitamin C), and a healthy lifestyle. How can I rejuvenate my face quickly? For a quick boost before an event, treatments like HydraFacial® or Gold Microinfusion provide instant radiance. For a more intensive, deeper rejuvenation, a fractional CO₂ laser treatment delivers significant results in a relatively short time, although it requires a few days of recovery. Is it possible to lift the face without surgery? Yes, there are several highly effective non-surgical lifting techniques. Thread lifts provide immediate mechanical lifting and stimulate collagen. Technologies like microneedling with radiofrequency and microfocused ultrasound tighten tissues deeply, gradually redefining facial contours. What type of serum should be used at 50? At 50, serums with concentrated active ingredients are ideal. In the morning, use a Vitamin C serum for antioxidant and brightening effects. In the evening, opt for a retinol- or peptide-based serum to stimulate cell renewal and collagen production. A hyaluronic acid serum can be used both morning and evening for deep hydration. How can I take 10 years off my face? “Taking 10 years off” is an achievable goal through an integrated full-face approach . This combines treating skin laxity, restoring lost volume (with fillers or Lipogems®), improving skin quality (with lasers and biostimulants), and relaxing expression lines. Such a comprehensive method restores a significantly younger and more refreshed appearance.

Vertical wrinkles marking the lip contour, commonly known as “barcode lines,” are among the most disliked blemishes, as they give the face a tired and severe appearance. At Istituto Image, we address this imperfection as both a challenge to correct and an opportunity to regenerate the skin in depth. Our philosophy is based on an approach that combines the most advanced techniques of aesthetic medicine, such as hyaluronic acid fillers and excellence regenerative protocols (Lipogems), to restore the smile’s natural harmony and freshness. Lip contour wrinkles: causes and characteristics The “barcode” lip contour consists of thin vertical wrinkles that form on the upper lip skin and, sometimes, on the lower lip as well. Their appearance is a multifactorial process, linked both to intrinsic aging and external factors. Over the years, the skin naturally loses collagen, elastin, and hyaluronic acid — the three pillars that give it tone, elasticity, and hydration. This structural thinning makes the skin more vulnerable to facial movements. The orbicularis oris muscle, which we constantly use to speak, smile, or drink, contracts repeatedly and marks the weakened skin, creating these fine lines. To this natural process, additional factors may accelerate and worsen the condition: Cigarette smoking: Nicotine compromises microcirculation and tissue oxygenation, while the very act of inhaling accentuates perioral muscle contraction. Sun exposure: Photodamage degrades collagen and elastin fibers, accelerating the loss of tone. Genetic factors: Individual predisposition plays a role in the early onset and severity of this imperfection. Dehydration: Poorly hydrated skin is less elastic and more prone to wrinkling. Understanding these causes is the first step toward defining a treatment strategy that not only fills wrinkles but also improves the overall quality of the skin. The importance of hyaluronic acid in aesthetic medicine Hyaluronic acid is an extraordinary molecule, naturally present in our body, particularly in the dermis. Its function is to bind and retain large amounts of water, acting as a true hydration reservoir that keeps the skin plump, elastic, and firm. In aesthetic medicine, the use of synthetic, biocompatible, and fully resorbable hyaluronic acid has been a true revolution. Fillers based on this molecule allow targeted and safe interventions to restore lost volume, correct asymmetries, and, of course, fill wrinkles. Its importance lies in its ability to provide natural, harmonious results without altering facial features. It is not a foreign body but a support that helps the skin regain its original structure, with an extremely high safety profile. How hyaluronic acid acts on lip contour wrinkles When a hyaluronic acid filler is injected to correct “barcode” lines, its action is dual and synergistic: Mechanical filling effect: the gel is precisely positioned in the wrinkle groove, lifting it from the inside and making the skin surface immediately smoother and more uniform. Biological added value: hyaluronic acid triggers deep hydration and biostimulation. By attracting water into tissues, it visibly improves skin hydration and plumpness. At the same time, its presence stimulates fibroblasts — the cells responsible for producing new collagen and elastin. This means that even after the filler is reabsorbed, the skin will maintain a stronger, more resilient structure, slowing the future reappearance of wrinkles. Parameter Average value / range Average onset age 35–45 years (earlier in smokers and individuals heavily exposed to the sun) Typical wrinkle depth 0.2 – 1 mm Percentage of smoker patients 60% of treated cases Average recovery time post-filler 24–48 hours for normal social activities Average duration of effect 6–12 months (longer when combined with regenerative protocols such as Lipogems) The treatment procedure with hyaluronic acid at Istituto Image At Istituto Image, every treatment begins with a personalized regenerative analysis. This medical consultation phase is crucial to understand the unique characteristics of the patient’s skin, the depth of wrinkles, and individual expectations. Only through accurate diagnosis can a truly tailored therapeutic plan be defined. The infiltration procedure is minimally invasive and performed on an outpatient basis. After applying a numbing cream to ensure maximum comfort, the physician proceeds with micro-injections of hyaluronic acid, using ultra-fine needles or microcannulas to distribute the product evenly and precisely. What sets our approach apart is our ability to integrate different methodologies for superior regenerative results. For deeper wrinkles and overall rejuvenation of the area, we often combine the filler with advanced technological treatments. The combination of laser therapies, such as fractional CO2 Laser, and Lipogems® technology represents the most advanced frontier of regenerative medicine. The laser acts on the surface, smoothing the skin and stimulating superficial collagen, while Lipogems® — a micro-fragmented adipose tissue harvested from the patient — works in depth, regenerating dermal structure thanks to its high concentration of mesenchymal cells. This synergy erases wrinkles and transforms skin quality, ensuring longer-lasting and natural results. Benefits and expected results of hyaluronic acid treatment A targeted treatment for lip contour wrinkles provides benefits beyond simple filling, contributing to overall rejuvenation of the smile and the lower third of the face. Main benefits include: Immediate and natural results: Wrinkles are immediately softened, with an effect that preserves facial expressiveness and harmony. Improved skin quality: Skin becomes more hydrated, firm, and elastic thanks to collagen stimulation. Effective prevention: The treatment slows down the formation of new wrinkles, acting as a true anti-aging therapy. Safety and biocompatibility: Hyaluronic acid is safe and completely resorbable. Prolonged duration: Filler effects last on average 6–12 months, but biostimulation benefits are longer-lasting. Post-treatment advice to maintain results over time To maximize treatment duration and effectiveness, it is essential to adopt certain good habits. Within 24–48 hours after injections, it is recommended to avoid exposure to intense heat sources such as saunas or tanning lamps, as well as refrain from intense physical activity. In the long term, a proper skincare routine including hydrating serums and daily sun protection (SPF 50+) is crucial to protect the skin from photodamage. Quitting smoking and maintaining excellent hydration by drinking plenty of water are simple but powerful gestures to preserve the skin’s beauty and health, prolonging the benefits achieved. Why settle for just filling a wrinkle when you can regenerate the skin in depth? At Istituto Image, our scientific approach integrates hyaluronic acid fillers with excellence protocols such as CO2 Laser and Lipogems® to guarantee not only immediate but visibly longer-lasting results. Choose a solution that treats the skin and prevents future aging. Contact us for an in-depth medical consultation and discover how our integrated method can transform your lip contour. FAQ How can I fill wrinkles around the lips? The most direct and effective method is the use of hyaluronic acid fillers, which fill the wrinkle groove and hydrate tissues. For more complete and long-lasting results, at Istituto Image we combine fillers with regenerative technologies such as CO2 Laser and Lipogems®, which improve skin quality from within. How long does hyaluronic acid last on the lips? The duration of lip contour fillers is subjective and depends on individual metabolism and lifestyle, but on average the volumizing and smoothing effect lasts 6 to 12 months. The benefits related to collagen biostimulation with Lipogems, however, are longer lasting. How to eliminate “barcode lines” around the lips? The most effective approach is multifactorial. Hyaluronic acid fillers provide immediate correction. For deeper regenerative action, treatments such as fractional laser, chemical peels, and especially Lipogems® technology stimulate new collagen production, improving skin texture and tone in the long term. How much does it cost to remove wrinkles around the mouth? The cost of treatment varies and depends on the type and amount of product used, as well as any combination with other technologies. To define a therapeutic plan and a personalized estimate, a specialist consultation with one of our aesthetic physicians is essential, who will recommend the most suitable strategy for your specific needs.