When We Talk About Leg Well-Being Visible capillaries, spider veins, and varicose veins are among the most common concerns. These signs are not just an aesthetic issue, they often reveal an underlying venous insufficiency that can lead to heaviness, swelling, and pain. For years, treatments have focused on closing or removing problematic vessels. Today, regenerative medicine has changed the rules of the game. At Istituto Image , we propose a revolutionary approach: Three-Dimensional Regenerative Phlebotherapy (TRAP) . This innovative method does not simply conceal the symptom, it acts on the cause, regenerating the venous system to restore the legs’ health, function, and beauty. It is a therapeutic pathway designed to re-establish the integrity of circulation, offering natural and long-lasting results. How TRAP Phlebotherapy Works: Principles and Mechanisms The principle behind TRAP is as simple as it is brilliant: to heal, not to close . Unlike traditional techniques aimed at occluding or removing visible veins, Three-Dimensional Regenerative Phlebotherapy works to regenerate the vessel walls. How is that possible? The treatment involves micro-injections of a solution containing sodium salicylate , a non-damaging concentration that, once in contact with the vein’s inner wall, triggers a structural recovery process. In practice, the solution stimulates a “contraction” and reinforcement of the venous wall, restoring its proper function. This mechanism re-establishes healthy blood flow and reduces the excessive pressure that caused dilation and the appearance of visible capillaries and varicose veins. The term “Three-Dimensional” is the key to its success: TRAP does not treat only the single visible capillary but the entire network of connected perforating and superficial vessels. This comprehensive approach allows the problem to be treated at its root, drastically reducing the risk of recurrence and improving the circulatory health of the entire leg. Advantages of TRAP Phlebotherapy Compared to Traditional Treatments Choosing the right treatment for varicose veins and capillaries deserves careful consideration. While traditional techniques have long been the standard, TRAP offers an entirely new paradigm, one focused on health and regeneration. Clinical experience and patient reviews highlight significant advantages. Here is a comparative summary table: Characteristic TRAP Phlebotherapy (Regenerative Approach) Traditional Treatments (Sclerotherapy, Laser) Approach Regenerative: heals and strengthens the venous wall. Destructive: closes (scleroses) or burns the vessel. Goal Restore the function of the entire three-dimensional venous network. Eliminate the single visible vessel. Aesthetic Result Disappearance of vessels with a natural effect, without stains or scars. Risk of hyperpigmentation (dark spots) or scarring. Functional Well-Being Improves circulation, reduces heaviness and swelling. Acts mainly on aesthetics, with limited functional impact. Recurrence Low recurrence rate, as it treats the underlying cause. More frequent, since the root cause (venous pressure) is not addressed. TRAP Phlebotherapy Procedure: What to Expect Undergoing TRAP means choosing a structured, safe, and personalized medical-aesthetic treatment. Each phase is designed to maximize efficacy and ensure comfort. Initial Consultation: Every treatment begins with a personalized consultation. Our specialist performs a clinical evaluation and, if needed, a Doppler ultrasound to map the venous system and identify the cause of circulatory insufficiency. This allows a customized therapeutic plan. Treatment Sessions: The procedure is performed on an outpatient basis and lasts about 30–45 minutes . The physician injects the regenerative solution using ultrafine needles in strategic points along the target veins. Discomfort is minimal. A full cycle generally consists of 4–6 sessions , scheduled every 2–4 weeks . Post-Treatment: After each session, it is essential to wear compression stockings to enhance the solution’s effect and support circulation. Avoid direct sun exposure and intense physical activity for a few days. Normal daily activities can be resumed immediately. For a synergistic and complete result , phlebotherapy can be combined with body mesotherapy (to drain excess fluids), shock waves (to improve cellulite and microcirculation), manual lymphatic drainage , and green clay wraps for a detoxifying and toning action. Results and Clinical Studies on TRAP Phlebotherapy The results of TRAP are both aesthetic and functional . From the very first sessions, patients experience a sensation of lightness and reduced swelling. Visually, varicose veins and capillaries gradually fade until they become invisible, leaving the skin smooth, even-toned, and healthy. The effectiveness of this approach is not merely anecdotal. Three-Dimensional Regenerative Phlebotherapy is supported by a growing body of clinical research confirming its principles. Studies show that the solution induces true vascular wall regeneration , ensuring stable, long-lasting results. Patient feedback consistently confirms a high level of satisfaction , not only for the disappearance of varicose veins but also for the regained feeling of leg well-being. Final Considerations and Future Perspectives Three-Dimensional Regenerative Phlebotherapy represents a paradigm shift in the treatment of venous insufficiency. It abandons the idea of “destroying” and embraces that of “healing and regenerating.” This perfectly aligns with the philosophy of modern medicine and, in particular, with the Istituto Image approach: leveraging the body’s intrinsic abilities to promote health and beauty harmoniously. The future of phlebology is moving in this direction — toward treatments that are less invasive, more physiological , and capable of providing long-term solutions. TRAP is not merely a leg treatment, but an investment in vascular health — a way to take care of yourself from the inside out. Frequently Asked Questions (FAQ) What is the TRAP technique? TRAP (Three-Dimensional Ambulatory Regenerative Phlebotherapy) is a non-surgical medical technique that treats varicose veins and capillaries. It consists of injecting a regenerative solution that strengthens the vein walls, restoring their function and improving circulation without removing or closing them. Does TRAP really work? Yes. TRAP is a clinically validated technique that targets the cause of venous insufficiency — the weakening of the vessel walls. By regenerating the venous structure, it not only eliminates the aesthetic issue but also provides long-term functional benefits, as confirmed by clinical experience and patient satisfaction. What are the side effects of TRAP? TRAP is a very safe procedure when performed by a qualified medical specialist. Minor and temporary side effects may include slight burning during injection, small bruises, or mild redness at the treated areas — all of which resolve within a few days. How does the TRAP method work? The method uses micro-injections of a sodium salicylate-based solution directly into visible veins and capillaries. This solution does not close the vessels but triggers a regenerative response that strengthens their walls. The treated veins constrict back to their normal size and become invisible, while overall leg circulation improves.

In the medical world, we are witnessing a silent yet powerful revolution: the transition from a “repair-oriented” to a “regeneration-focused” approach. We are no longer satisfied with masking symptoms or replacing what has been damaged — we seek to awaken the body’s innate ability to heal itself. Within this new paradigm, regenerative medicine stands out as a true game changer, especially in treating joint and musculoskeletal disorders that affect millions of people worldwide. At Image Regenerative Clinic , we have been pioneers in this field, developing the Lipogems® methodology thanks to the intuition and research of Professor Carlo Tremolada . However, for those new to this world, confusion often arises. We hear about PRP , stem cells , Lipogems® , but what are the differences? And more importantly, which is the most suitable option? Let’s clarify this by analyzing two of the most discussed regenerative treatments: PRP and Lipogems® . What Is Regenerative Medicine? Before diving into specifics, it’s essential to understand the core concept. Regenerative medicine is not a miraculous cure, but a biological and intelligent approach that leverages the body’s own self-healing mechanisms. Its goal is simple yet ambitious: to use the patient’s own biological resources (blood or adipose tissue) to repair, rebuild, or regenerate tissues damaged by aging, trauma, or chronic diseases such as osteoarthritis. This minimally invasive approach represents a valid alternative to traditional pharmacological treatments or, in many cases, to prosthetic surgery. PRP: Principles and Applications PRP , short for Platelet-Rich Plasma , is one of the most well-known regenerative techniques. The procedure is relatively simple: a small amount of blood is drawn from the patient, then centrifuged to separate its components and concentrate the platelets. The resulting plasma, rich in growth factors, is then injected into the joint or damaged tissue. These growth factors act as powerful messengers, sending biochemical signals to surrounding cells to initiate an anti-inflammatory response and trigger tissue repair. PRP is commonly used to treat tendinopathies, muscle injuries, and early stages of osteoarthritis , where it helps reduce pain and improve functionality. However, it is important to note that PRP mainly provides signaling molecules to stimulate repair, but its effect is typically short-lived . The Lipogems® Method: How It Works Lipogems® represents a major advancement in regenerative medicine, a globally patented system developed by Professor Carlo Tremolada. Unlike PRP, which originates from blood, Lipogems® harnesses the regenerative potential of adipose (fat) tissue , an extraordinarily rich biological resource. The procedure, performed in a sterile environment and on an outpatient basis, involves just a few steps: Harvesting: a small and painless lipoaspiration under local anesthesia, usually from the abdomen or flanks. Processing: the collected fat is inserted into the Lipogems® device , a closed sterile system that gently microfragments the tissue and washes it with saline solution, removing inflammatory and oily residues while preserving the regenerative microenvironment. Injection: the resulting microfragmented and purified fat tissue is then injected precisely into the damaged area under ultrasound guidance. The Lipogems® tissue contains not only growth factors , but also a complete biological matrix : mesenchymal stem cells (MSC) , pericytes , and stromal vascular components that act as natural “healers,” orchestrating a profound and lasting regeneration process. PRP vs. Lipogems®: Advantages and Limitations While both treatments are valid regenerative options, they act on different biological levels and are suited for different clinical scenarios. In simple terms, PRP is a “stimulator” , whereas Lipogems® is a true “regenerator.” Characteristic PRP (Platelet-Rich Plasma) Lipogems® Biological Source Patient’s blood Patient’s adipose tissue Active Component Platelet growth factors Mesenchymal stem cells, pericytes, and stromal matrix Mechanism of Action Cellular stimulation and signaling Complete regenerative process (provides both “builders” and “materials”) Effect Duration Temporary (months) Long-lasting (up to 3–5 years) Main Indications Tendinopathies, mild osteoarthritis Moderate to severe osteoarthritis, cartilage lesions, chronic pain Procedure Type Blood draw and centrifugation Mini-lipoaspiration and same-day tissue processing Lipogems® is considered one of the most advanced next-generation joint injections , particularly effective for damaged cartilage , where simple stimulation is insufficient. In some regions, mesenchymal cell injections are even recognized by national health systems for specific pathologies, confirming their clinical validity. Clinical Cases and Real Experiences The efficacy of Lipogems® is supported by over 175 scientific publications and the experience of thousands of patients . In the sports field, it has been awarded “Best New Technology in Sports Medicine” and is used by elite athletes from Serie A, NBA, and NFL to accelerate recovery and protect joint health. But its benefits go far beyond sports. Consider a 60-year-old man with knee osteoarthritis, chronic pain, and limited mobility, his only remaining option seemed to be a prosthesis. After years of ineffective conservative therapies, he underwent a Lipogems® treatment. Just a few months later, his pain had dramatically decreased, his joint function improved, and he was able to walk and resume normal activities without limitations. This is not an exception, but a powerful example of the regenerative potential within each of us . Final Thoughts and Future Perspectives in Regenerative Medicine The choice between PRP and Lipogems® is not about which is “better” in absolute terms, but which is most appropriate for the specific clinical condition, degree of degeneration, and patient goals. While PRP remains a valuable option for mild inflammatory and degenerative conditions, Lipogems® stands out as the treatment of choice for more significant tissue damage, offering deep regeneration and long-lasting results . The future of orthopedics, and medicine in general, is already taking shape: less invasive, more biological, and deeply personalized . In this landscape, technologies like Lipogems® , which transform a natural body resource into a powerful healing tool, are no longer a promise — they are a solid clinical reality .

At Istituto Image, we approach personal well-being with a method that integrates scientific innovation and a deep understanding of the body’s biological mechanisms. For this reason, we offer cutting-edge solutions for painful and disabling conditions such as Morton’s Neuroma. Our goal is not only to relieve symptoms but to act on the root cause of inflammation through advanced regenerative therapies, such as the Lipogems technology , to provide effective and lasting relief and improve quality of life. What is Morton’s Neuroma? Morton’s Neuroma, despite its name, is not a tumor or neoplasm, but a benign degenerative condition affecting one of the interdigital nerves of the foot. It is a perineural fibrosis, meaning a thickening of the connective tissue surrounding the nerve, caused by chronic irritation or mechanical compression. This condition most commonly develops in the space between the third and fourth toes, an area anatomically more prone to stress and microtrauma. The increase in fibrous tissue volume compresses the nerve, triggering painful and bothersome symptoms that can become disabling in daily activities. The sensation is often described as having a “pebble in the shoe,” a persistent discomfort that prevents normal walking. Common Symptoms of Morton’s Neuroma in the Foot Nerves The symptoms of Morton’s Neuroma are very characteristic and tend to worsen with tight footwear or physical activity, then ease with rest and by removing the shoes. Recognizing them is the first step toward a correct diagnosis. The most common signs include: Sharp, burning pain: Mainly localized in the forefoot, at the base of the toes. Foreign body sensation: The feeling of having a pebble, a bead, or a fold in the sock under the foot. Electric shocks or tingling: Pain and numbness radiating towards the affected toes. Toe cramps: The sensation of toes “overlapping” or sudden cramps. Immediate relief when removing shoes: A typical and almost instinctive gesture is taking off footwear and massaging the area to find relief. Main Causes of Morton’s Neuroma Morton’s Neuroma is a condition caused by mechanical overload. Inflammation and the subsequent nerve thickening are the body’s response to compression or repeated stress over time. Understanding the causes is essential to set an effective prevention and treatment strategy. The pain under the foot at the base of the toes is the main warning sign, which can appear as sudden sharp stabs to the toes, sometimes radiating into more generalized discomfort that also affects the big toe area due to altered walking mechanics. The main risk factors include: Risk Factor Description and Impact on the Nerve Inadequate Footwear The most common cause. Prolonged use of high heels, narrow-toed, or ill-fitting shoes forces the forefoot into an unnatural position, increasing compression and pressure on the interdigital nerves. Biomechanical Dysfunctions Alterations in posture or foot morphology (e.g., flatfoot, high-arched foot, hallux valgus, hammer toes) change weight distribution on the forefoot. This imbalance favors irritation and inflammation of the nerve. High-Impact Activities Sports such as running and dancing, or jobs requiring standing for many hours, cause repeated microtrauma to the forefoot, continuously stressing the area and nerves. Direct Trauma A single injury or direct blow to the foot can damage the nerve and trigger the acute inflammatory process that leads to neuroma formation. Diagnosis: How to Recognize Morton’s Neuroma An accurate diagnosis is essential to distinguish Morton’s Neuroma from other foot conditions with similar symptoms (such as stress fractures, bursitis, or arthritis). The diagnostic pathway is based on two key steps: Clinical Examination: The specialist collects the patient’s history, analyzing the type of pain and habits (work, sports, footwear). During the visit, they perform targeted palpation of the intermetatarsal area. A specific test, the “Mulder’s sign,” consists of lateral compression of the forefoot: if this maneuver elicits a painful “click,” the diagnosis of Morton’s Neuroma is highly likely. Imaging Diagnostics: Ultrasound is the first-choice test, as it accurately shows the fibrous thickening of the nerve and allows measurement of its size. In doubtful cases, or to exclude other pathologies, MRI may be requested, providing a more detailed view of the soft tissues and bone structures of the foot. Medical Treatments for Walking with Morton’s Neuroma The aim of treatment is to reduce nerve compression, alleviate inflammation, and resolve pain. The approach is gradual, starting with the most conservative solutions and moving toward more innovative options. Conservative Therapies: The first step includes the use of custom orthotics to offload the metatarsal area, the choice of comfortable, wide-toe footwear, and cycles of physiotherapy (physical therapies such as tecar therapy or laser and stretching). Corticosteroid Injections: If pain persists, cortisone injections can reduce inflammation, providing relief that is often temporary. Regenerative Medicine with Lipogems®: At Istituto Image, we offer a regenerative approach as an alternative to traditional therapies. Treatment with Lipogems® consists of infiltrating micro-fragmented adipose tissue harvested from the patient. This tissue is rich in mesenchymal cells with strong anti-inflammatory and regenerative properties. The infiltration creates a natural cushion that protects the nerve from compression, reduces inflammation in a lasting way, and stimulates tissue repair processes. Surgery: If other therapies fail, surgical intervention is performed, consisting of removing the neuroma (neurectomy). Although definitive, the surgery results in loss of sensitivity in the affected area. Prevention and At-Home Care Strategies Prevention is the best cure for Morton’s Neuroma. Adopting a few simple habits can drastically reduce the risk of developing this bothersome condition or worsening its symptoms: Choose the Right Shoes: Opt for comfortable footwear with a wide toe box that does not compress the toes and a heel no higher than 3–4 cm. Alternate different shoes throughout the week. Use Orthotics: If foot support is incorrect, a custom orthotic can make the difference by distributing weight evenly. Manage Acute Phases: In case of pain, apply ice to the affected area for 15–20 minutes and keep the foot at rest. Stretching Exercises: Regularly stretching the calf and sole muscles can help reduce tension on the forefoot. 👉 Contact our specialists and book a consultation to define the most effective treatment pathway for you! FAQ Why does Morton’s Neuroma form? Morton’s Neuroma forms due to chronic compression and irritation of an interdigital nerve in the foot. The main causes are tight or high-heeled shoes, alterations in foot shape (e.g., hallux valgus), or repeated microtraumas from certain sports or work activities. How can Morton’s Neuroma inflammation be reduced? It can start with conservative remedies such as rest, ice application, and comfortable footwear. Medically, corticosteroid injections can reduce inflammation. An advanced and natural alternative is regenerative therapy with Lipogems®, which has a powerful anti-inflammatory and regenerative effect. Can Morton’s Neuroma heal on its own? It is very unlikely for Morton’s Neuroma, being a fibrotic degeneration of nerve tissue, to heal spontaneously. However, symptoms may regress and be controlled by adopting proper conservative measures (adequate shoes, orthotics) and avoiding triggers. How do I know if I have Morton’s Neuroma? Typical symptoms are burning pain in the forefoot, the sensation of having a “pebble in the shoe,” and tingling in the toes, which worsen with tight shoes. For a certain diagnosis, a specialist consultation is essential, including clinical examination (with Mulder’s Test) and ultrasound. What is the treatment for Morton’s Neuroma? The treatment follows a gradual approach: it starts with conservative methods (orthotics, proper footwear, physiotherapy). If these are insufficient, infiltrative therapies (cortisone or regenerative medicine such as Lipogems®) are considered. Surgical removal of the neuroma is reserved for cases that do not respond to other therapies.

At Istituto Image, we conceive skincare as a scientific and personalized journey, aiming to restore skin health and balance from within. We know that acne is not just a cosmetic concern but a condition that can deeply affect psychological and physical well-being. For this reason, we offer advanced therapeutic protocols that go beyond traditional treatments. Among our most innovative solutions, the Kleresca® treatment represents a true revolution in aesthetic dermatology — a non-invasive and clinically tested option to treat acne effectively while respecting the skin’s physiology. Kleresca treatment: what it is and how it works The Kleresca® treatment is a technological leap in modern dermatology, based on a unique scientific principle: biophotonic technology. Unlike lasers, peels, or topical drugs, Kleresca® does not act aggressively on the skin but stimulates its natural repair mechanisms at the cellular level. Its functioning relies on the synergy of two key elements: A photo-converter gel: A patented chromophore gel is applied to the treatment areas. This gel contains special pigments capable of converting light of a specific wavelength into fluorescent light energy. A multi-wave LED lamp: The skin is exposed for about nine minutes to high-intensity LED light. This light activates the gel, generating fluorescent light energy (FLE) that penetrates deep into the dermis. This light energy acts on multiple levels: it eliminates the bacteria responsible for acne (Cutibacterium acnes), reduces inflammation, normalizes cellular activity, and stimulates the production of new collagen. In practice, Kleresca® “teaches” the skin to repair itself, working with its biological processes and not against them. The benefits of Kleresca treatment for acne-prone skin The advantages of a Kleresca® program are multiple and go beyond the mere reduction of pimples. The biophotonic approach offers an overall improvement in skin health, with visible and lasting benefits. Anti-inflammatory and antibacterial action: The treatment reduces the inflammation that causes redness and swelling in acne lesions and eliminates P. acnes bacteria, directly addressing two of the main causes of acne. Stimulation of collagen production: Fluorescent light energy stimulates fibroblasts to produce new collagen. This not only improves skin texture but also helps repair and reduce post-acne scarring. Normalization of cellular activity: The treatment helps rebalance sebum production, reducing the oily shine typical of oily skin and minimizing the visibility of enlarged pores. Safety and comfort: It is a non-invasive, painless procedure free from significant side effects. It does not cause photosensitivity, making it safe to perform any time of the year, even in summer. To better understand its positioning compared to traditional methods, here is a comparative table: Characteristic Kleresca® Topical Treatments (Creams/Acids) Oral Therapies (Antibiotics/Isotretinoin) Mechanism of Action Stimulation of cellular regeneration through biophotonic energy. Chemical exfoliating or antibacterial action on the skin surface. Systemic action to reduce bacteria, inflammation, or sebum production. Invasiveness Non-invasive. Generally non-invasive, but may cause irritation and dryness. Systemic invasiveness, with possible side effects at the whole-body level. Side Effects Minimal and transient (mild redness). Irritation, dryness, flaking, photosensitivity. Severe dryness, photosensitivity, gastrointestinal issues, requires monitoring. Recovery Time None. Normal activities can be resumed immediately. Variable, from none to a few days of flaking. None, but side effects may persist. Year-round Safety Safe year-round, even in summer. Often discouraged in summer due to photosensitivity. Requires strict medical supervision and often not suitable long term. The Kleresca treatment process: what to expect during a session A Kleresca® session is a comfortable and relaxing experience performed in the clinic under the supervision of our specialized therapists. The protocol is simple and well structured: Cleansing: The skin is thoroughly cleansed to remove makeup and impurities, preparing it for treatment. Gel application: The Kleresca® photo-converter gel is applied evenly to the targeted areas (face, neck, or décolleté). LED light exposure: The patient sits under the LED lamp for about 9 minutes. During this phase, a pleasant warmth and intense light may be perceived, so protective goggles are provided. Removal and hydration: At the end of the exposure, the gel is gently removed, and a soothing moisturizer is applied to complete the treatment. The entire session lasts about 30 minutes. No anesthesia is required, and patients can immediately resume daily activities after the session. Expected results of Biophotonic therapy: how long until improvements are visible? Kleresca® results are progressive and continue to improve over time, even after completing the treatment cycle. The effectiveness of biophotonic therapy lies in its ability to stimulate deep regeneration that requires time to fully manifest. A standard acne protocol typically involves 4–6 sessions, performed weekly or biweekly. The first improvements, such as reduced inflammation and redness, are often visible after the initial sessions. As treatment progresses, a decrease in active lesions and an improvement in skin texture are observed. The collagen production benefits continue for months after the last session, leading to firmer, smoother skin with reduced scarring. Patience and consistency are rewarded with natural and long-lasting results. Safety considerations and possible side effects Safety is one of the strengths of the Kleresca® treatment. Being a non-invasive and non-systemic procedure, it does not carry the risks associated with medications or aggressive laser treatments. The treatment is clinically tested and considered very safe. Side effects are rare, mild, and temporary. Some patients may experience slight redness or minimal temporary hyperpigmentation in treated areas, usually resolving within hours or days. No specific preparation is required before the session and, as mentioned, there is no downtime, allowing the treatment to be easily integrated into a weekly routine. Why choose istitutoimage.it for Kleresca treatment Choosing Istituto Image means relying on a team of professionals who believe in an integrated and scientific approach to acne care. We don’t just perform a single treatment but build a complete and personalized pathway. Our acne protocol, supervised by doctors and therapists, often combines Kleresca® with other synergistic methods to maximize results: Hydrafacial®: As a preparatory treatment, it deeply cleanses and hydrates the skin, making it more receptive to biophotonic therapy. Chemical peels: Used alternately or after the Kleresca® cycle, they help refine skin texture and treat post-inflammatory spots. Oxygen Ozone Therapy: Its antibacterial and regenerative properties enhance Kleresca®’s effect, accelerating tissue healing. Each program is complemented by a home routine with specific cosmeceutical products, designed to maintain and enhance clinical results. This 360-degree approach ensures not only the resolution of the imperfection but the achievement of optimal and lasting skin health. Are you tired of the usual treatments that irritate the skin without lasting results? The Kleresca® biophotonic therapy is a real revolution: a non-invasive method that stimulates your skin to regenerate and fight acne from within, without side effects. It’s time to try a different approach, based on your skin’s biology. Book a specialist consultation at Istituto Image and discover how our personalized Kleresca® protocol can restore clear and radiant skin. FAQ What are the contraindications of the Kleresca treatment? The Kleresca® treatment is very safe but is generally contraindicated during pregnancy, in cases of epilepsy, or when taking photosensitizing medications. A preliminary consultation with a specialist is always required to assess suitability. What is the most effective cure for acne? The most effective cure is a personalized one. For inflammatory and persistent acne, a non-invasive approach like Kleresca® has proven highly effective because it targets the causes (inflammation and bacteria) and stimulates skin regeneration, preventing scars. Maximum effectiveness is achieved when the treatment is integrated into a medical protocol that also includes other therapies and a proper home skincare routine. What is the Kleresca method? The Kleresca® method is a non-invasive biophotonic therapy that uses the combination of a photo-converter gel and an LED light to generate fluorescent light energy. This energy penetrates deeply into the skin, reducing inflammation, eliminating bacteria, and stimulating collagen production to treat acne and improve skin health. How to make acne disappear permanently? Acne is a chronic condition requiring a long-term approach. To manage it definitively, an integrated medical program addressing both internal and external causes is necessary. Protocols combining advanced therapies such as Kleresca®, peels, and proper home care, together with a healthy lifestyle, offer the most stable and lasting results. What is the Kleresca rosacea treatment? It is a specific formulation of the Kleresca® protocol designed to treat rosacea symptoms. It works by reducing inflammation, redness, and papulopustular lesions typical of this condition. Biophotonic therapy helps calm reactive skin and improve microcirculation, providing relief and improving skin appearance.

Knee osteoarthritis, or gonarthrosis, is a degenerative condition that affects millions of people, undermining quality of life with pain, stiffness, and movement limitations. If you've been diagnosed with it or live daily with these symptoms, you know how frustrating it can be. Traditional therapies, such as hyaluronic acid injections, often offer only temporary relief. But today, the frontier of medicine has shifted toward a more promising horizon: regeneration. At Istituto Image, under the scientific guidance of Professor Carlo Tremolada, a pioneer in this field, we offer a revolutionary approach to treating knee osteoarthritis. Through the minimally invasive Lipogems methodology for knee osteoarthritis, we harness your own body's regenerative potential to address the problem at its root, offering an effective and lasting solution, often with a single application. What is Knee Osteoarthritis: Main Causes and Symptoms Knee osteoarthritis is a chronic condition that develops when cartilage, the smooth and elastic tissue covering the ends of bones in the joint, progressively wears down. This protective layer, as it thins, loses its ability to cushion movements, causing bone surfaces to rub against each other. The causes are multifactorial and include: Aging: Natural wear and tear is one of the main factors. Overweight and obesity: Excess weight increases the load on knees, accelerating cartilage deterioration. Previous trauma: Fractures, ligament injuries (such as ACL) or meniscus damage can trigger post-traumatic arthritic processes. Genetic factors: There is a family predisposition to developing the condition. Demanding work or sports activities: Professions or sports involving repeated joint overload. Initial symptoms are often mild and intermittent, later becoming more constant and debilitating. The most common include: Pain: Initially present during movement, like climbing stairs or after exertion, it can become constant even at rest or during the night. Joint stiffness: Especially in the morning or after long periods of inactivity. Swelling: Often associated with joint effusion. Functional limitation: Difficulty fully bending or extending the knee. Crackling and crunching: Sensation of "sand" inside the joint during movement. Osteoarthritis Diagnosis: When to Consider Lipogems Treatment An accurate diagnosis is the fundamental first step. The journey begins with a specialist orthopedic consultation, during which the doctor will evaluate the patient's clinical history and knee joint mobility. Instrumental examinations like X-rays are essential to confirm the diagnosis, showing joint space reduction and the presence of any osteophytes (small bone growths). In some cases, an MRI may be requested to assess soft tissue status, such as menisci and ligaments. The choice to consider Lipogems® treatment emerges as the option of choice at a specific point in the patient's therapeutic journey. Typically, this occurs when conservative strategies, such as physical therapy or anti-inflammatory drugs, can no longer offer adequate pain control, leaving the person in a state of chronic suffering. Similarly, many patients turn to us after experiencing the limitations of hyaluronic acid injections, which, while offering relief, prove to be a temporary solution with benefits that vanish within 3-6 months, requiring repeated treatment cycles. Lipogems® therefore presents itself as the ideal solution for those seeking a biological and natural approach that directly taps into their body's self-healing potential. It represents a concrete strategy for those who want to postpone, and in many cases avoid, the need for invasive surgical intervention such as knee prosthesis implantation. How Do Stem Cell Injections for the Knee Work? Lipogems® is not a simple injection, but a true regenerative medicine treatment. The procedure, devised and patented by Professor Carlo Tremolada, is based on using adipose tissue harvested from the patient themselves, a biological resource extraordinarily rich in mesenchymal (stem) cells and pericytes, key elements for tissue regeneration. The process is minimally invasive and takes place in a single outpatient session: Harvesting: Through a small liposuction performed under local anesthesia, a minimal amount of adipose tissue is collected, usually from the abdomen or flanks. Processing: The harvested fat is inserted into the Lipogems® device, a closed and sterile system that, through a mechanical micro-fragmentation process, purifies the tissue, eliminating oily and inflammatory components and concentrating cells with high regenerative potential. Injection: The purified and activated tissue is then injected directly into the knee joint, under ultrasound guidance to ensure maximum precision. Once injected, these cells act as a natural "repair team," releasing growth factors and anti-inflammatory cytokines that orchestrate a regeneration process. Benefits and Results: What to Expect from Treatment Unlike hyaluronic acid, which acts primarily as a lubricant with a temporary effect, Lipogems® promotes true biological healing. The benefits are concrete and lasting: Anti-inflammatory Action: The injected cells modulate the joint's inflammatory environment, leading to rapid and significant pain reduction. Regeneration Stimulation: Released growth factors stimulate cartilage cells to repair themselves, slowing the degenerative process. Functionality Improvement: Reduced pain and inflammation translate into improved mobility, flexibility, and ability to walk without limitations. Results are not only immediate but progressive. Many patients experience significant relief within the first weeks, with benefits that continue to consolidate in subsequent months and can last for years, often with a single application. Lipogems Treatment: Procedures, Duration, and Precautions The Lipogems® procedure is performed on an outpatient basis and has a total duration of about 60 minutes. It's a safe technique, as it uses the patient's own tissue (autologous), eliminating any risk of rejection or allergic reaction. Precautions: Before treatment, a specialist evaluation is essential to confirm the patient's suitability. After the procedure, a brief period of relative rest is recommended, avoiding excessive loads on the joint for the first few days. Return to normal daily activities is generally very quick. Lifestyle and Tips to Enhance Treatment Effectiveness To maximize and extend the benefits of Lipogems® treatment, it's essential to adopt a healthy lifestyle. Although our approach is aimed at regenerating from within, some precautions can make a big difference: Weight Control: Maintaining adequate body weight reduces the load on the knee joint, decreasing mechanical stress and slowing cartilage wear. Low-Impact Physical Activity: Sports like swimming, cycling, or walking on flat surfaces are ideal for maintaining joint mobility, strengthening thigh musculature (which acts as a natural shock absorber for the knee) without overloading the joint. Anti-inflammatory Diet: A diet rich in fruits, vegetables, omega-3 fatty acids (found in oily fish and nuts) and low in refined sugars and processed foods can help reduce systemic inflammation, supporting the healing process. Targeted Physical Therapy: A personalized rehabilitation program, developed in synergy with regenerative treatment, is crucial for recovering full functionality, improving balance and posture. Addressing knee osteoarthritis today means looking beyond palliative solutions. Regenerative medicine with Lipogems® offers a concrete possibility to change the course of the pathology, not only managing symptoms but promoting deep and lasting healing. Frequently Asked Questions (FAQ) How long does it take to see effects in the knee? The first benefits in terms of pain and inflammation reduction can be felt just a few weeks after treatment. However, the regenerative process is gradual: results continue to improve progressively over the next 3-6 months, with benefits that can last for years. How much does regenerative medicine technique for the knee cost? The cost of Lipogems® treatment is defined following a specialist medical evaluation, as it depends on the patient's specific condition and case complexity. It's important to note that, being a therapeutic procedure for orthopedic purposes, in many cases it's reimbursed by major private health insurance companies. How much should you walk with knee osteoarthritis? Physical activity is fundamental, but it must be low-impact. Walking on flat and soft surfaces is recommended, avoiding steep ascents or descents. A 20-30 minute walk per day is generally beneficial for maintaining mobility and strengthening muscles.

By Professor Carlo Tremolada – Scientific Director of Image Regenerative Clinic Following the marketing authorization granted by AIFA on October 9, 2024, tirzepatide is now officially approved in Italy for the treatment of obesity and overweight in individuals with at least one comorbidity, alongside diet and physical activity. At the European level, the Commission has endorsed its use for adults with a BMI of 30 or above, or starting from 27 in the presence of risk factors. As of February 23, 2025, Mounjaro (tirzepatide) is also reimbursable for the treatment of type 2 diabetes and available through electronic prescription. A Cutting-Edge, Scientifically Grounded Approach Professor Tremolada, with his extensive clinical and research background, sees the use of microdoses not as a shortcut but as a key element within a regenerative, multidisciplinary therapeutic model . This method moves beyond the simplistic goal of weight loss, addressing the underlying metabolic and functional dynamics of the body. In a cultural context where weight loss is often seen merely as a matter of aesthetics or willpower, this vision marks a paradigm shift: the focus is on the biological terrain, not just the visible symptom. Through functional assessments, personalized nutritional coaching, continuous clinical monitoring, and targeted treatments for body composition, the process becomes a structured experience—designed to build long-term well-being. The Value of Microdosing in a Lasting Transformation Calibrated use of tirzepatide allows for the gradual restoration of a more efficient metabolic profile, avoiding the abrupt accelerations that often lead to relapse. Appetite control becomes more natural, without frustration or rigidity. The intervention goes deep, offering benefits that extend well beyond weight: improved insulin sensitivity, reduced inflammation, enhanced mental clarity, and better sleep quality. All of this contributes to more organic adherence to the program, with a body that begins to function more smoothly. It’s not about “resisting hunger,” but about rewiring the dysfunctional impulses that drive overeating. This is a biological reprogramming—measured, intelligent, and continuous . A Proven and Recognized Clinical Pathway At Image Regenerative Clinic, the weight loss program is built entirely around the individual. It begins with an in-depth evaluation of the person’s medical, metabolic, and functional profile. From there, a tailor-made protocol is developed, combining microdoses with targeted nutrition, mindful movement, and regenerative support to preserve lean mass and muscle tone. Professor Tremolada has always embraced an integrated perspective—combining clinical science with technological innovation, while breaking through the cultural barriers that often stand in the way of real change. This is the core of an approach that doesn’t promise shortcuts, but offers real, sustainable, and measurable transformation . Discover our Weight Loss Body Program now

With summer just around the corner, taking care of your skin isn’t just a matter of aesthetics—it’s a matter of health. Discover how to prevent skin cancer with innovative treatments like ALA Photodynamic Therapy and Kleresca® photobiomodulation, available at Image. Protecting your skin, all year long especially in summer. Why skin cancer prevention matters as the warmer season approaches In a world where beauty and wellbeing are increasingly intertwined, Image Regenerative Clinic stands out as a trusted destination not only for aesthetics, but for skin health too. Our integrated approach combining aesthetic medicine, dermatology, and surgery allows us to provide patients with highly specialized, comprehensive, and personalized care. Medicine beyond beauty. As spring arrives and sun exposure increases, it’s important to shine a light on a crucial topic for skin health: the prevention of skin cancer. Among the most common types are basal cell carcinoma and squamous cell carcinoma—forms of skin cancer that, while often less aggressive than melanoma, should never be underestimated. The first step in prevention is awareness Non-melanoma skin cancers mainly affect photo-exposed areas—face, ears, neck, hands—and are more likely to develop in individuals with fair skin or a history of intense and prolonged sun exposure. That’s why prevention must begin before summer, with proper education and responsible behavior. The dermatological check-up: a simple act that makes all the difference Primary prevention is the most powerful ally in protecting your skin. Regular dermatology visits —especially in the presence of suspicious lesions, moles that change in shape, color or size, or small persistent scabs—are the most effective tool for early diagnosis. At Image Regenerative Clinic, prevention is a core part of a multidisciplinary approach to both skin health and beauty. Our specialists perform detailed mole mapping and targeted check-ups, even during times of year when the risks of sun exposure tend to be underestimated. Treatments: from non-invasive to surgical In the case of a skin cancer diagnosis, early treatment is key. At Image, a variety of therapeutic options are available—tailored to each patient and depending on the location and nature of the lesion. Among the non-invasive treatments , highlights include: ALA Photodynamic Therapy (aminolevulinic acid): a targeted and conservative treatment that uses a photosensitizing agent activated by a specific light source to selectively destroy abnormal cells. It is particularly effective for superficial or actinic lesions and helps prevent progression to more aggressive forms. Kleresca® Photobiomodulation, an innovative technology that stimulates the skin’s natural repair processes through clinically tested fluorescent light. It offers both preventive and regenerative benefits and can be used as part of a maintenance protocol—even following photodynamic therapy. When necessary, dermatologic surgery can be performed using refined techniques designed to achieve the best oncological and aesthetic outcome—especially important for tumors located in visible areas such as the face. Sun exposure with awareness Using sunscreen, wearing hats and sunglasses, avoiding sun exposure during peak hours—these are small everyday habits that can significantly contribute to prevention. But it’s only through a culture of continuous and conscious care that we can truly protect our skin. With summer on the horizon, choose to take care of yourself. Book your skin cancer prevention check-up at Image and consult with our specialists about a personalized protocol —which may include ALA Photodynamic Therapy and Kleresca® Photobiomodulation . Because your skin’s health is also your beauty . Image Regenerative Clinic – Medicine Beyond Beauty.

In-depth article by Dr. Fabrizio David , regenerative medicine specialist at Image Regenerative Clinic. Supporting NAD (Nicotinamide Adenine Dinucleotide) levels through targeted IV therapies is now considered one of the most promising strategies in the field of longevity. This isn’t a passing trend, but a clinical approach backed by growing scientific evidence, capable of enhancing cellular energy, mitochondrial function, DNA repair, and oxidative stress response—key processes in slowing biological aging. Like any truly effective therapy, NAD requires careful medical assessment, personalized protocols, and a structured clinical setting to ensure real, safe, and lasting results. Not a Miracle Cure, But a Powerful Tool NAD is not an over-the-counter supplement or a one-size-fits-all solution. It’s a vital molecule for cellular metabolism that naturally declines with age and in the presence of chronic conditions. Restoring or supplementing its levels can translate into increased vitality, improved stress management, faster recovery, and enhanced cognitive and physical performance. But timing, dosage, and method of administration are crucial—and must always be determined under expert medical guidance. At Image Regenerative Clinic, every treatment begins with a comprehensive analysis of the patient’s metabolic and inflammatory status, including: Complete hematochemical and metabolic panel; Evaluation of key micronutrients involved in NAD synthesis (vitamin B3, B12, folic acid, vitamin D, zinc); Markers of oxidative stress and inflammation; Indicators of mitochondrial function; Only through this detailed workup can we determine whether NAD IV therapy is appropriate and set up a protocol that is truly effective. NAD IV Therapy and an Integrated Approach When indicated, intravenous NAD therapy allows for rapid and direct absorption, with noticeable effects often after just a few sessions. Depending on individual needs, it may be combined with custom infusions of vitamins, minerals, amino acids, and antioxidants, all tailored to the patient’s specific metabolic profile. This therapeutic strategy is part of a broader, holistic program that may include: Nutritional optimization Targeted physical activity Stress management strategies Continuous long-term monitoring Why Choose a Clinical Setting In a world where everything seems readily available, what makes the difference is the context. NAD IV therapies are not treatments to be improvised. They require medical expertise, structured protocols, and meticulous follow-up. Only in a specialized clinic like Image can patients receive the level of care needed to ensure safety, efficacy, and true personalization. Longevity is about making informed choices—not chasing miracles. Investing in your long-term health means relying on structured, science-based programs guided by clinical insight. When used consciously and under expert supervision, NAD can become an extraordinary ally .

How new therapeutic tools, lifestyle habits, and medical monitoring can help us live better and longer In recent years, the concept of healthy longevity has taken center stage in medical and societal conversations. It's no longer just about adding years to life: the challenge is to add life to years—by preventing chronic diseases, slowing degenerative processes, and maintaining mental and physical balance. But what can we do when the body begins to slide toward a condition of unhealthy longevity? The answer is not a shortcut, but a multidisciplinary path. That’s exactly the premise behind the Weight Loss Body Program developed by Image Regenerative Clinic —a structured approach to regaining health and vitality through a personalized, integrated program under strict medical supervision. Healthy longevity: a daily construction As explained in the “Code of Healthy Longevity” , aging can be modulated. Proper nutrition, physical activity—especially strength training—restorative sleep, stress management, and targeted supplementation (vitamin D, Omega-3s) are essential to slow the inflammatory processes that underlie many chronic and degenerative diseases. A study published in Nature Aging showed that combining vitamin D, Omega-3s, and physical exercise can slow biological aging, even influencing epigenetic markers Similarly, Omega-3 supplementation has proven useful in preventing autoimmune diseases and low-grade silent inflammation. When lifestyle is not enough: the role of new molecules In some cases, despite best efforts, the body can no longer respond effectively. You enter a grey area marked by excess weight, sleep apnea, muscle loss (sarcopenia), and rising inflammation markers . Here, advanced pharmacological tools—under strict medical supervision—can be helpful. Drugs like semaglutide (Ozempic®) and tirzepatide (Mounjaro®) , originally developed for type 2 diabetes, have shown revolutionary potential for healthy longevity , thanks to their ability to: Significantly and sustainably reduce body weight Improve insulin sensitivity Regulate appetite and reduce caloric intake Improve inflammation markers Act on multiple target organs (liver, kidneys, central nervous system) According to a study published in the New England Journal of Medicine , tirzepatide led to a 22.5% reduction in body weight in people with obesity—greater than the reduction seen with semaglutide Moreover, an analysis published by Quotidiano Sanità shows that, when used appropriately, these molecules also provide added benefits for cardiovascular, hepatic, and neurodegenerative health , as well as improved sleep quality in people suffering from obstructive sleep apnea. Real limits, avoidable risks These drugs are not miracle pills. Used outside a structured framework, they can lead to rapid weight regain—often at the expense of muscle mass . This is especially risky in older adults, where sarcopenia is one of the key threats to healthy aging. A study published by SIO Obesità emphasizes the importance of combining these therapies with resistance training to preserve muscle tissue and support metabolic health. Image Regenerative Clinic: an integrated protocol for conscious longevity To prevent misuses and risks, Image Regenerative Clinic has developed a personalized Weight Loss Body Program that includes: Comprehensive medical evaluation Tailored nutritional support Targeted physical training (especially strength exercises) Innovative therapies only when needed and always under medical supervision Regular follow-ups to ensure stability, safety, and long-term results The goal is not simply to “lose weight” but to restore health , slow aging , and prevent chronic diseases associated with unhealthy longevity. Each intervention is part of a larger, individualized framework designed for long-term balance and well-being. No miracles, just conscious choices Ozempic® and Mounjaro® are powerful tools, but only become truly effective when integrated into a structured, medically guided journey. Used in isolation, without a complete lifestyle reset, the risk of relapse is high. True healthy longevity does not come from a single drug. It stems from the smart combination of prevention, science, and an integrated vision of health . https://www.youtube.com/watch?v=f2pSXS7ArtY And this is exactly where the real transformation begins.

In recent years, scientific research has opened new frontiers in tissue regeneration, offering innovative solutions for the treatment of joint disorders, skin rejuvenation, and much more. One of the most advanced methods, backed by scientific research, is Lipogems® , a patented system developed by Professor Carlo Tremolada of Image Regenerative Clinic in Milan. This technology harnesses micro-fragmented adipose tissue (MFAT) , rich in mesenchymal stem cells and natural growth factors , to support tissue repair and regeneration in a safe, effective, and minimally invasive way. What are the Most Promising Clinical Applications of Lipogems®? Lipogems®: Innovation in Regenerative Medicine for Joints, Skin, and More Regenerative medicine is transforming the medical landscape, offering advanced solutions for various conditions. Among these innovations, the Lipogems® system stands out for its effectiveness and versatility . Developed and patented by Professor Carlo Tremolada at Image Regenerative Clinic in Milan, Lipogems® utilizes micro-fragmented adipose tissue to promote tissue regeneration across multiple medical fields. What is Lipogems®? Lipogems® is a technology that processes autologous adipose tissue through a closed and sterile system , without the use of enzymes or chemical substances. This method preserves the integrity of mesenchymal stem cells and pericytes , which play a crucial role in tissue regeneration. The result is a standardized-quality product , ready to be used in various clinical applications. Clinical Applications Orthopedics : Lipogems® is used in the treatment of osteoarthritis and tendinopathies , helping reduce pain and improve joint function . Beauty : In the aesthetic field, Lipogems® is applied for skin rejuvenation, volume correction, and overall skin quality improvement . Gynecology : The system is used to treat post-menopausal vulvovaginal atrophy , improving tissue elasticity and hydration . Coloproctology : Lipogems® shows potential in treating anal fistulas and fissures , offering a regenerative approach that promotes faster and less invasive healing compared to traditional methods. Crohn’s Disease : A clinical trial is currently underway at Sant'Orsola Hospital in Bologna , where Lipogems® is being studied for the treatment of perianal complications associated with Crohn’s disease. Chronic Wounds and Diabetic Foot : Lipogems® is used in the treatment of diabetic foot ulcers and other complex wounds , leveraging the regenerative properties of adipose tissue to accelerate healing and reduce infection risks . Lipogems® represents a breakthrough in regenerative medicine , offering effective and minimally invasive solutions for a wide range of conditions. Ongoing research and advancements in application techniques will further expand its potential, improving the quality of life for many patients .

The debate between acceptance and health In recent years, the concept of Body Positivity has gained popularity, promoting acceptance of all bodies and countering weight-related stigma. It's a positive principle that has helped valorize diversity and combat discrimination. However, in some cases, the evolution of this movement has led to an extreme view, where any discussion about health related to weight is perceived as an attack on individual freedom. This leads us to reflect on the importance of a balanced approach, where respect for oneself and others combines with awareness of health risks. It is therefore fundamental to distinguish between acceptance and well-being, understanding how body weight influences our overall health. Health cannot be sacrificed in the name of inclusivity. Obesity is not just an aesthetic issue, but a concrete risk factor for longevity and quality of life. Several studies have shown that being overweight increases the risk of chronic diseases such as type 2 diabetes, hypertension, cardiovascular diseases, and some types of cancer. The New England Journal of Medicine has highlighted that obesity can reduce life expectancy by up to ten years, depending on the severity of the case. These data help us understand how essential it is to address the issue of weight with a perspective based on science and long-term well-being, rather than on superficial judgments or radical ideologies. The role of science in weight management Within this complex discussion lies the Body Positivity movement, born with the intent to promote self-acceptance, fight discrimination, and value the diversity of bodies. However, in recent years, it has become radicalized to the point of challenging anyone who talks about weight loss, spreading the idea that promoting a healthy lifestyle equates to "fatphobia." This attitude risks dissuading people from making informed decisions for their health, leaving them trapped in conditions that compromise their quality of life. Accepting one's body doesn't mean ignoring the risks associated with obesity: true awareness comes from balance, that is, appreciating oneself without neglecting the impact that body weight has on metabolism, internal organs, and the ability to maintain optimal energy over time. Faced with this complexity, scientific research has developed solutions for weight control, aimed at improving quality of life without falling into extremism. Innovation has led to the creation of drugs such as Mounjaro (tirzepatide) and Wegovy (semaglutide), which have demonstrated their ability to promote weight loss in a safe and sustainable way, improving vital parameters such as blood glucose, cholesterol, and blood pressure. These solutions open new perspectives for those struggling with overweight and obesity, but they are not exempt from criticism. Some commentators have contested them, arguing that they contribute to reinforcing the stigma of obesity. However, it is essential to understand that these treatments are not an aesthetic solution, but medical tools that can significantly improve the health of those suffering from pathological obesity. The importance of a balanced approach Looking at the longest-lived societies in the world, we discover an interesting fact: weight management should not be seen as an imposition, but as an opportunity to live better and longer. Research on longevity shows that the populations of Blue Zones share a common aspect: maintaining a balanced body weight through healthy eating and constant physical activity. The benefits of an optimal BMI include better blood glucose control and diabetes prevention, reduced risk of cardiovascular diseases, lower levels of inflammation and oxidative stress, and increased vitality and quality of life. The discussion on weight and health cannot be reduced to an ideological clash between "skinny versus fat." The real goal must be well-being, based on informed choices supported by science. It's not about adhering to aesthetic standards imposed by society, but about living longer and better. Instead of fueling sterile debates, we should focus on what truly matters: a healthy, active life full of energy. At Image Regenerative Clinic, we adopt a scientific and personalized approach to help our patients achieve their maximum potential for well-being and longevity. We are ready to support you on this journey with advanced medical solutions and personalized strategies for your well-being.

50 and 60 years? They're the new 40! Today, women in their 50s and 60s live with energy and awareness, dedicated to their wellbeing and eager to take care of themselves. However, menopause brings physiological changes that can affect quality of life, including vaginal dryness, painful intercourse, urinary discomfort, and recurring inflammation. These symptoms are often neglected or considered inevitable, but science proves otherwise. Research conducted for Image Regenerative Clinic has highlighted how vaginal discomfort is perceived as a real but rarely discussed problem. Due to modesty or embarrassment, many women avoid discussing it, even with their partner, and seek solutions only when symptoms become limiting. It's time to change this approach and consider intimate health as an integral part of overall wellbeing. Lipogems: The Natural Solution for Intimate Wellness A study published in European Review for Medical and Pharmacological Sciences by Doctors Casarotti and Tremolada demonstrated the efficacy of Lipogems, an innovative treatment that harnesses the regenerative power of adipose tissue to improve vaginal mucosa hydration and elasticity. How Does Lipogems Work? Lipogems is a regenerative medicine treatment utilizing autologous adipose tissue to stimulate cellular renewal. The process begins with harvesting a small amount of fat, which is then purified and microfragmented to obtain a concentrate rich in mesenchymal cells. This preparation is subsequently injected into vaginal tissues, promoting natural and progressive regeneration. Documented benefits include increased elasticity and hydration of vaginal mucosa, enhanced sensitivity and comfort, and reduced dryness and pain during intercourse. Unlike other solutions, Lipogems offers long-term results through its ability to stimulate microcirculation and structural tissue renewal. Lipogems vs. Laser Therapy: The Real Difference Until now, laser therapy has been one of the most common techniques for treating vaginal atrophy, acting through thermal microlesions to stimulate collagen production. Although effective, many patients find it uncomfortable and with time-limited effects. The true difference between the approaches lies in vascular regeneration. While laser therapy is limited to superficial action on already compromised tissues, Lipogems promotes new blood vessel formation, improving microcirculation and ensuring stable, lasting tissue restoration. Prof. Carlo Tremolada's Commentary: "The laser approach creates a stimulating action on tissue that has already lost much of its regenerative capacity. Lipogems, however, works by enhancing microvascularization and tissue elasticity naturally and progressively. This means the improvement isn't just aesthetic or temporary, but structural and lasting. True regeneration." A New Vision for Intimate Health Vaginal health should be considered part of overall wellness, not exclusively linked to sexual function. Lipogems offers a comprehensive solution for intimate wellness, reducing dryness, irritation, and even recurrent cystitis. This scientifically advanced and completely natural approach uses no hormones, doesn't alter physiological balance, and exclusively utilizes the patient's own regenerative capabilities.

Rhizarthrosis is a degenerative disease of the thumb joint, particularly painful and debilitating, primarily affecting women over 40 and during menopause. A clinical study demonstrates that Lipogems regenerative medicine not only resolves pain but promotes cartilage repair and progressive healing from rhizarthrosis. We discuss this with Image Regenerative Clinic experts, Professor Carlo Tremolada, Scientific Director, and Dr. Laura Loda, hand surgeon, who are the authors of the clinical study. Can rhizarthrosis be treated without surgery? In the clinical study conducted on 45 patients (36 females and 9 males aged 41-77 years) at Image Regenerative Clinic in Milan, Lipogems regenerative medicine with MFAT adipose tissue transplantation demonstrated promotion of cartilage healing in thumb joints affected by rhizarthrosis. The Lipogems autologous fat transplantation, performed through intra-articular injection, proved effective in both early-stage and advanced severe thumb osteoarthritis. Traditional therapies include conservative treatments (non-surgical) with intra-articular corticosteroid or hyaluronic acid injections, custom splints, physiotherapy, and surgical interventions (trapeziectomy, prosthesis, arthrodesis) indicated when conservative therapy proves ineffective. Both conservative and surgical treatments provide significant symptom relief but with functional limitations and cannot promote cartilage regeneration or prevent the underlying arthritic process. How does Lipogems regenerative therapy work for rhizarthrosis? Lipogems regenerative therapy for rhizarthrosis is performed through intra-articular injection of autologous adipose tissue harvested via minor liposuction from the patient's abdomen or thighs and microfragmented using a specific device (Lipogems - patented by Professor Carlo Tremolada). As demonstrated by extensive scientific literature, autologous adipose tissue contains high levels of progenitor cells (pericytes, mesenchymal stem cells, growth factors) which, when injected into the thumb joint, promote cartilage tissue formation. Additionally, the injected Lipogems tissue acts as a cushion for the worn joint, preventing direct contact and abrasion between articular surfaces, reducing pain. Study results demonstrate that following the post-operative rehabilitation program is essential for optimal regenerative treatment outcomes. Lipogems regenerative treatment can be repeated if rhizarthrosis symptoms recur, including treatment of the other hand or arthritic pain in other joints, without requiring repeated liposuction for autologous fat harvesting. Through Lipobank, patients can cryopreserve their fat tissue for future use.

At Image Regenerative Clinic, any time is suitable for hair transplantation. With the regenerative hair transplant method, patients can undergo the procedure and return to their normal activities within a few hours. When Should You Undergo Regenerative Hair Transplantation? The innovative hair transplantation technique performed at Image Regenerative Clinic, which utilizes the regenerative capacity of hair follicles, can be scheduled at any time of the year, including summer or before vacations. The procedure allows for minimally invasive extraction and transplantation of follicles from the nape to the desired area. After the procedure, patients can resume normal daily activities, including vacations, with only the precaution of wearing a hat and avoiding strenuous activities in the immediate post-operative period. What Does Utilizing the Follicle's Regenerative Capacity Mean? Each hair follicle has an intrinsic capacity for hair regeneration. The Image method preserves and stimulates the natural regenerative capacity of cells in each transplanted hair follicle. The follicles, extracted from the nape (donor area) and transplanted through micro-holes in the recipient area, immediately promote regeneration and growth of new hair, along with natural scalp healing. Post-procedure micro-holes become nearly invisible within hours, without forming crusts or visible scarring. Generally, only mild and transient scalp irritation occurs. How Long Until Hair Transplant Results Are Visible? Hair growth from transplanted follicles is natural, progressive, and lasting, with visible results within a few months. Transplanted hair maintains the same quality and structure as the donor area hair, ensuring superior resistance to hair loss compared to traditional techniques. The donor area at the nape remains reusable for potential subsequent procedures, maintaining the available follicle capital. Although the number of transplantable follicles may be lower compared to traditional techniques, this method is particularly suitable for those wishing to preserve the donor area or for patients with limited follicle availability in the donor zone.

Joint pain has various causes, from inflammation to trauma, as well as osteoarthritis, tendinitis, and bursitis. Generally, joint pain can be treated with medications, conservative therapies like physiotherapy, and joint injections. However, in many cases, these therapies are insufficient or don't provide the benefits achievable through regenerative medicine and surgery. We discuss this with Professor Carlo Tremolada, Specialist in plastic and reconstructive surgery and maxillofacial surgery, expert in regenerative medicine and surgery, inventor of the Lipogems® patent and Scientific Director of Image Regenerative Clinic. For all these patients, Lipogems offers a non-surgical alternative for treating musculoskeletal injuries, having demonstrated in numerous independent studies superior clinical results compared to other conservative treatments. Furthermore, this therapy has scientifically proven to be more effective than other regenerative medicine options that use only stem cells or platelet factors. What are the benefits of articular Lipogems? Lipogems treatment for joints is a minimally invasive procedure that has demonstrated reduced pain and inflammation, improved mobility and functionality of damaged joints and tissues, drastically reduced recovery times, and improved outcomes of certain surgical procedures it can be combined with, such as rotator cuff repair, while also reducing the risk of post-operative complications. Although it is a minimally invasive procedure, Lipogems treatment is performed in an operating room and requires brief observation time in the clinic after injection. Lipogems is an autologous procedure, using the patient's own fat tissue, thus eliminating the risk of allergic reactions or rejection. The treatment requires the use of a cannula under local anesthesia in the abdominal area, which leaves no scarring, to extract fat tissue with a special syringe, similar to mini-liposuction. The fat microfragmented within the Lipogems device through a specific mechanical action becomes MFat Lipogems, a tissue extremely rich in active regenerative cells that is grafted, takes root, and continues to produce benefits long-term. Based on the patient's joint condition and symptoms, treatment may need to be repeated in 1-2 years, as in cases of severe osteoarthritis; in all other cases, one injection is sufficient for complete healing. When the procedure needs to be repeated, is a new extraction necessary? It is not necessary to perform a fat extraction each time the Lipogems injection needs to be repeated. A single adipose tissue extraction can be performed with a larger quantity than needed for a single injection and then cryopreserved. Fat cryopreservation for regenerative use is known as banking and allows preservation of all vital characteristics and properties of the freshly extracted adipose tissue for up to 6 years. Cryopreserved fat for regenerative use is stored in the first Italian Lipobank in Cesena, authorized by the National Transplant Center and the Regional Transplant Center of Emilia Romagna, where adipose tissue extracted with the Lipogems system is processed, validated, and stored for all regenerative purposes. Using internationally certified (TUV) adipose tissue cryopreservation and thawing technology that meets the highest safety and sterility standards, the fat can be used in the future for both subsequent joint injections and other regenerative uses, such as regenerative facelifts, as filler for facial aesthetic rejuvenation, volumetric procedures like breast reconstruction, and treatment of various pathologies and disorders. Currently, only fat extracted with the Lipogems processing system can be preserved: lipoaspirate, which is mainly used for volumetric procedures, and/or Lipogems for regenerative procedures is authorized for banking by the National Transplant Center.

Understanding cellular aging mechanisms has led to insights into how environment, habits, and lifestyle help slow aging, followed by the development of new drugs targeting specific mechanisms that can decelerate cellular aging, and ultimately to discovering truly effective therapies to halt and slow tissue aging. We discuss this with Professor Carlo Tremolada, Researcher and Director of Image Regenerative Clinic. Supplements and Off-label Medications Supplements that increase NAD (nicotinamide adenine dinucleotide) levels are primary candidates for anti-aging therapies. NAD is crucial for cellular metabolism and longevity, with studies dating back to 1997 when David Sinclair, professor of genetics at Harvard Medical School, discovered that NAD can help regulate a family of proteins called sirtuins, which improve epigenetic health and increase longevity in yeast. This led to interest in resveratrol, a polyphenol found in red wine and used in many supplements, to activate sirtuins. A recent study (Cell Metabolism, 2024) examined promising supplements and off-label medications for slowing aging, including Metformin (primarily used for type 2 diabetes), NAD precursors, Glucagon-like peptide-1 (GLP-1) receptor antagonists, TORC1 inhibitors involved in growth and aging, Spermidine, Senolytics, Probiotics, and Anti-inflammatories. However, their effectiveness on aging and longevity remains a subject of debate in the scientific community. Off-label medications and supplements remain controversial, with ongoing discussions about their efficacy. Cellular Reprogramming Caloric Restriction The effects of caloric restriction on longevity (in laboratory subjects) have been discussed since the 1990s, but it wasn't until 2007 that a major multi-year clinical study called the Calerie Study analyzed the effects of caloric restriction in humans. Recent findings demonstrate that subjects on lower-calorie diets showed reduced inflammation and increased production of immune system T-cells and energy-producing mitochondria. Subsequently, studies on intermittent fasting or time-restricted feeding in mice suggest that such routines could suppress genes involved in inflammation and improve protein production, even at advanced ages. Infiltrative Therapies with Mesenchymal Stem Cells Distinct from umbilical cord or bone marrow stem cell therapies still under study and debate, infiltrative therapies with mesenchymal stem cells are already part of clinical practice for treating various conditions. Among these, the Lipogems regenerative system, patented by Professor Carlo Tremolada, is widely used worldwide by physicians for treating cellular aging and chronic conditions like osteoarthritis. Lipogems is a minimally invasive regenerative procedure that utilizes autologous adipose tissue, rich in mesenchymal stem cells and growth factors, to promote tissue regeneration. The procedure maintains the intact perivascular niche of adipose tissue, ensuring the survival and efficacy of mesenchymal stem cells in the regenerative process.

At Image Regenerative Clinic, our hair transplant method for treating alopecia, baldness, or significant hair loss is derived from reconstructive surgery. Initially developed for burn patients, this technique preserves over 80% of donor follicular units, and the same donor area can be utilized for future hair transplants. We discuss this with Professor Carlo Tremolada, Scientific Director of Image Regenerative Clinic. Characteristics: Utilizing the Regenerative Capacity of Hair Follicles The innovative aspect of our technique lies in the follicle extraction method, which promotes the natural regenerative capacity of cells in each transplanted hair follicle. The procedure involves extracting hair follicles from the occipital region (nape area) using a 0.6-millimeter microblade. This extraction technique facilitates new hair growth in the harvested follicle and allows the scalp to heal without scarring. The extracted hair is then transplanted into the desired area through microscopic incisions that disappear within hours, without crust formation and with minimal scalp irritation. This results in natural and lasting hair growth with the same quality and structure as the donor area, maintaining stability over time. Benefits: No Scarring, Immediate Recovery The primary advantage of our innovative hair transplant technique is achieving a perfect, natural result visible within months. This outcome is often unattainable with traditional techniques, where severe cases may face donor hair depletion over time. Additionally, patients can resume daily activities immediately post-transplant, with no scarring, pain, or need for follow-up dressings. While the number of transplantable hairs per session is lower compared to other techniques, the procedure is repeatable until achieving optimal results. The donor area in the nape region remains reusable multiple times without scarring, maintaining the available hair supply. However, the cost of this regenerative follicular transplant technique may exceed that of alternative methods. Who Is Eligible for Our Hair Transplant? Our innovative hair transplant technique is particularly suitable for individuals with baldness who lack sufficient donor hair for traditional transplantation, or for those seeking to preserve their donor area for optimal results. Hair Loss: What Other Treatments Are Effective? Alopecia, or baldness, affects millions worldwide, significantly impacting quality of life. Based on condition severity, various treatment options are available, including hair fillers, but hair transplantation remains the most effective solution for achieving lasting, natural-looking results.

Over the years, both men and women can develop anal disorders that negatively impact quality of life. During menopause, vaginal atrophy may accompany the emergence of uncomfortable anal border irregularities. Regenerative medicine using the Lipogems method offers an innovative and effective treatment opportunity for both anal regeneration and total pelvic floor regeneration. We discuss this with Dr. Alberto Giori, proctologist surgeon at Image Regenerative Clinic, and Professor Carlo Tremolada, scientific director of Image Regenerative Clinic. What are the main anal disorders that appear with age? The most frequent anal disorders that appear with age are anal skin tags and anal polyps, in addition to hemorrhoids which are more of a disease than a disorder. Anal skin tags are excessive skin growths whose origin can be traced to friction phenomena and inflammatory episodes in the anal region. Anal polyps are generally fibroepithelial in nature and only rarely can be neoplastic. Like skin tags, polyps develop on the anal border but can also originate from the internal epithelium of the terminal portion of the anal canal. These are functional and aesthetic anal disorders that can negatively impact people's quality of life. What are the symptoms of anal skin tags and polyps? These disorders can create discomfort in intimate relationships, not only from an aesthetic perspective but also from functional and psychological standpoints, leading to limitations in one's sexuality. How are anal skin tags and polyps treated with regenerative medicine?

Sometimes when lifting your baby or performing common hand movements, you may experience pain at the base of your thumb and wrist. The pain, triggered by gripping movements between thumb and index finger or repeated wrist flexion, often accompanied by swelling, may be caused by De Quervain's Disease, also known as mother's wrist. We discuss this with Dr. Laura Loda, hand surgeon at Image Regenerative Clinic. What is De Quervain's Disease? De Quervain's Disease is inflammation of the sheaths covering two thumb tendons called the abductor pollicis longus and extensor pollicis brevis. It's sometimes called mother's disease because new mothers often extend their thumbs maximally when lifting their babies, causing tension in these tendons. It is primarily a degenerative condition that initially manifests as painful friction during tendon movement and increased synovial inflammatory fluid (exudative phase). If untreated shortly after symptom onset, the condition becomes chronic, synovial fluid production stops, and the tendon sheath thickens, causing obstruction of tendon movement through the canal (nodular phase). What are the symptoms of De Quervain's Disease? Common signs and symptoms include gradual onset of swelling and pain in the wrist and near the thumb base. The pain may radiate along the forearm and can cause difficulty in performing daily activities, such as grasping objects with an extended thumb and fully flexed or extended wrist. Advanced cases may present with tingling along the dorsal aspect of the thumb. What causes De Quervain's Disease? De Quervain's Disease can be caused by various factors, though the most evident connection is repetitive stress on the abductor pollicis longus and extensor pollicis brevis tendons and wrist. These movements are common in daily activities such as using keyboards, mice, musical instruments, and infant care. Other risk factors include microtrauma, anatomical variations, hormonal changes during pregnancy, rheumatoid arthritis, and genetic predisposition. How is De Quervain's Disease diagnosed? Diagnosis is primarily clinical, based on specialist evaluation during examination and specific tests where the physician grasps the patient's thumb and pulls it toward the little finger, triggering pain if De Quervain's Disease is present. In some cases, ultrasound may be necessary to reveal alterations in affected tendons and their relationship with canal walls. What is the treatment for De Quervain's Disease? Initial stages warrant conservative treatment. This includes corticosteroid injections, anti-inflammatory and analgesic medications, ultrasound, tecar therapy, shock waves, ozone therapy, braces, kinesio taping, and avoiding repetitive manual work. Regenerative therapy with Lipogems tissue is also indicated in early stages, utilizing the regenerative properties of mesenchymal cells in adipose tissue to reduce inflammation and promote tissue healing. In chronic stages and when conservative treatments fail to provide lasting results, surgical release of De Quervain's canal becomes necessary. The procedure is performed under local anesthesia in an outpatient setting, involving a skin incision on the external wrist margin centered on the first extensor compartment, and retinaculum release allowing tendon movement without pain or friction. Post-surgery hand movement is possible without protective braces. Care should be taken to keep the wound clean and avoid excessive loads for approximately 10 days. Physiotherapy is recommended to prevent scar adhesions and promote faster functional recovery.

You may wake up in the morning or during manual work to find a finger locked and stiff in a bent position. This can affect chefs, musicians, painters, smartphone and computer users, as well as athletes. It's an unpleasant sensation, as if the finger catches or clicks during flexion-extension movement. If this occurs, you may have Notta's disease, or stenosing tenosynovitis of the flexor tendons, more commonly known as trigger finger. We discuss this condition with Dr. Laura Loda, hand surgeon at Image Regenerative Clinic. What is trigger finger and what causes it? Risk factors for trigger finger include gender and age, with women and people over 40 being more susceptible, as well as certain medical conditions (diabetes, hypothyroidism, rheumatoid arthritis, gout, connective tissue diseases, and congenital digital canal stricture causing trigger finger in children). What are the symptoms of trigger finger? Symptoms of trigger finger include swelling at the base of the finger, tenderness at the finger base which may reveal a small nodule upon palpation, movement difficulty, finger clicking, and finger locking in flexion or extension. How is trigger finger diagnosed? Trigger finger diagnosis is made during specialist examination through clinical evaluation and palpation of the tendon thickening that causes pain at the base of the finger. What are the treatment options for trigger finger? In early stages, conservative treatment is indicated, which may include arnica, ice, corticosteroid injections, anti-inflammatory and analgesic medications, ozone therapy, ultrasound, laser therapy, tecar therapy, more frequent breaks from repetitive manual work, and splinting. Post-operative physiotherapy treatment by a physical therapist is recommended to prevent scar tissue adhesions and enable faster, more satisfactory recovery.

What is Osteoarthritis? Osteoarthritis is a progressive degenerative condition of cartilage (degenerative chondropathy) that, in severe cases, affects the bones of mobile joints. Osteoarthritis can affect any joint in the human body: knee (gonarthrosis), hip (coxarthrosis), ankle, elbow, thumb (rhizarthrosis), spine, and shoulder. Initially, micro and macro lesions appear in the cartilage, triggering inflammatory responses characterized by pain, swelling, and progressive joint stiffness. Osteoarthritis is the leading cause of disability in people over 65, with prevalence increasing with age (particularly over 75). According to current literature, osteoarthritis is characterized by anatomical and/or physiological alterations including cartilage degradation, bone remodeling, osteophyte formation (bone spurs), joint inflammation, and loss of normal joint function. Osteoarthritis significantly impacts quality of life, progressively leading to activity limitations, restrictions in active life and sports, sleep disturbances due to nocturnal pain, tendency toward depression, loss of independence, and reduced quality of life. Generally, individuals don't seek help until they experience pain, which often indicates that articular cartilage condition is already significantly compromised and osteoarthritis is advanced. With standard therapies, spontaneous disease remission is not possible, and structural damage to cartilage, articular bone, and consequently ligamentous, meniscal, and tendinous structures eventually leads to arthroplasty (joint replacement). How Can Regenerative Medicine Treat Osteoarthritis? Adipose tissue is the ideal source for extracting and utilizing mesenchymal stem cells (MSCs), as it can be easily accessed and harvested through minimally invasive surgery, is available in sufficient quantities in most individuals, and provides adequate quantities of progenitor cells with good viability and differentiation potential minimally dependent on age. Lipogems technology uses gentle mechanical forces to obtain a micro-fragmented regenerative product with cells that maintain high specific differentiation properties. Mechanically derived mesenchymal stem cells (MSCs) have demonstrated better differentiation potential, richer bioactive molecule composition (secretome), and significant differences in sophisticated cell content (exosomes) that transport nutrients, genetic material, growth factors, and tissue-specific angiogenic factors, such as for knee cartilage or any other joint. With these characteristics, as demonstrated in literature, MFat Lipogems tissue has a higher degree of efficacy and safety in the regenerative treatment of cartilage and bone tissues damaged by symptomatic osteoarthritis, even in advanced stages.

For several years, adipose tissue has been gaining increasing interest as an ideal source of mesenchymal stem cells for regenerative treatment of various pathologies and degenerative processes affecting our organism. While the use of isolated or cultured mesenchymal stem cells remains subject to safety and efficacy concerns, Lipogems technology, currently available in 27 countries worldwide, offers a completely natural and safe way to utilize the regenerative properties of adipose tissue. Lipogems processes even minimal quantities of adipose tissue in a completely closed system, harvested with minimal trauma from a donor site (abdominal region, flanks, gluteal region, thighs). The adipose tissue processing eliminates inflammatory components (oil, blood, cellular debris) and reduces cluster size, resulting in a homogeneous and highly manageable final product suitable for intra-articular infiltration of shoulder, knee, hip, ankle, and other tendinous and ligamentous structures. The resulting micro-fragmented adipose tissue preserves intact adipose niches - the fundamental morpho-functional units of the tissue - with their vasculo-stromal network where mesenchymal stem cells and their precursors can optimally perform their regenerative function. This is the key distinction between Lipogems technology and traditional methods using mesenchymal stem cells: preserving the natural microenvironment of the adipose niche to maintain the regenerative potential of stem cells and their functions. Lipogems technology utilizes minimally manipulated adipose tissue rather than cellular fractions extracted from it. Ideal for Arthritis and Inflammatory Lesions of Tendons and Ligaments, and Beyond The primary orthopedic indications for Lipogems regenerative treatment include degenerative arthritic processes affecting articular cartilage (degenerative chondropathy), degeneration and/or inflammatory lesions of menisci and all peri-articular tendinous and ligamentous structures causing pain and limited joint functionality. Lipogems can also accelerate any healing process when combined with surgical procedures. The entire procedure can be performed under local anesthesia with optional sedation (recommended for anxious patients or those with poor compliance), takes approximately one hour, and requires no post-operative hospitalization. After adipose tissue harvesting and processing, articular infiltrations are performed immediately using standard technique or under ultrasound guidance to precisely identify the target structure. Tissue regeneration is a long process that occurs and amplifies over the first six months, progressively increasing joint functionality and improving quality of life, often avoiding the need for invasive surgical procedures. For information and appointments: info@istitutoimage.com (+39) 02 7628 0736

The inventor of the Lipogems® method speaks at a conference on new regenerative medicine techniques. On June 9th at 17:30, at the Grand Hotel Gardone in Gardone Riviera, an important meeting on new frontiers of regenerative medicine, sponsored by Lipogems International, will take place. Image's Scientific Director, Professor Carlo Tremolada, will speak alongside another internationally renowned expert in regenerative lipofilling, Dr. Bryan C. Mendelson, to explore applications and techniques in regenerative lipofilling. Dr. Giovanni Botti from Villa Bella Clinic, organizer of the Botti's Best Breast Congress, will moderate the conference, which Professor Tremolada will attend from June 10-12. Lipogems® Lipogems® is the first regenerative medicine treatment applied in aesthetic medicine. The system involves harvesting, processing, and grafting autologous adipose tissue in a single surgical procedure, using a safe, practical disposable device. The specific processing eliminates pro-inflammatory residues and activates mesenchymal cells, naturally present in our body, which have the capacity to promote damaged tissue regeneration. The graft is performed using various techniques depending on the desired effect. Treatment areas include face, lips, cheekbones, and breast, combining volumetric and regenerative effects for evident, long-lasting, yet natural results. The meeting will analyze both grafting techniques and clinical evidence of treated cases. Lipogems® is ideal for numerous aesthetic applications including: lower eyelid bags correction, hand rejuvenation, breast deformity correction, and body contouring improvements. Image & Lipogems® Image The Urban Medi Spa is the first center of excellence in regenerative medicine. Through Lipogems®, which extraordinarily accelerates the natural tissue regenerative and reparative process, it is now possible to treat various conditions conservatively and with remarkable results, including degenerative joint arthrosis (knee, ankle, hip) and musculotendinous problems (Achilles tendon, rotator cuff, plantar fasciitis). For more information about the Lipogems® system and to discover all its applications, please contact Image The Urban Medi Spa by completing the information request form on our website, calling us at 02-781628, or visiting lipogems.eu.

The human body consists of cells, small functional units tasked with collaborating and performing various functions to ensure proper organism functioning. Every human action produces an 'adaptive' bodily response to the received stimulus, from basic activities like eating, moving, and sleeping, to more complex actions like sports, working, and healing from trauma. The Self-Healing Principle From birth, the human organism possesses all biochemical-physiological prerequisites for self-healing and tissue regeneration following tissue damage. It must first ensure individual growth and subsequently maintain health, being ready to respond to both positive and negative stimuli. Osteopathy incorporates this concept as one of its foundational pillars: through precise assessment of movement, signs, symptoms, and general body signals, it employs techniques on all directly and indirectly accessible tissues to communicate with the nervous system and enable optimal physiological healing conditions. Osteopathic therapy, combined with strengthening/maintenance/neuromotor reprogramming exercises, can modify an individual's posture, optimally aligning body segments for improved general and specific function. Lipogems Sustaining damage during developmental years (0-20 years), when healing factors and regenerative capabilities are at peak efficiency, differs significantly from injury in adult or advanced age, particularly regarding recovery time, healing quality, restorative tissue quality, and healing capacity. Additionally, certain body tissues are poorly vascularized or lack blood vessels entirely, such as articular cartilage, menisci, specific bones like the scaphoid or talus, and ligaments in knees, shoulders, and ankles. This creates conditions where damage to these structures may be irreversible and prone to continuous degeneration. Lipogems technology stimulates natural regenerative processes through autologous mesenchymal cells derived from adipose tissue, enabling affected tissues to regenerate and heal. When is Manual Therapy Combined with Lipogems Indicated? This combination is indicated for degenerative tissue pathologies with progressive prognosis, chronic inflammatory conditions, post-surgical complications, and cases requiring prevention of significant degeneration or improvement of body tissue quality. Primary indicated conditions include: osteoarthritis, meniscal disorders, tendinopathies, calcifications, fibrosis, partial ligament injuries, musculotendinous lesions, impingement (shoulder, hip), arthritis, and TMJ degenerative pathologies. The Synergistic Mechanism Osteopathy addresses dysfunction, restores correct biomechanics and function by interacting with the nervous and proprioceptive systems, effective when target tissues can respond positively and heal. When pathology develops and degenerative factors emerge, Lipogems provides an innovative solution to halt and often reverse this process, enabling even severely damaged tissues with limited healing capacity to regenerate efficiently and systematically. The therapeutic approach is individually tailored, combining osteopathy and Lipogems to achieve and maintain optimal function. The physiological mechanisms underlying healing stimulation are supported by scientific and clinical evidence, while the synergy and efficacy of the combined therapeutic approaches are validated by our clinical experience.

Microfractured Adipose Tissue Injections (Lipogems) for the Treatment of Vaginal Disorders The postmenopausal estrogen decline can cause various symptoms that reduce quality of life: an estimated 10-40% of postmenopausal women experience vaginal, urinary, and sexual function disorders due to local atrophy related to hormonal decline. Available therapeutic options are limited and sometimes contraindicated, such as hormone therapy in cases with oncological risk. In this context, regenerative medicine offers a new therapeutic option for women with this significant condition. Lipogems has demonstrated excellent results in enhancing sexual pleasure and treating dyspareunia (pain during sexual intercourse), vulvodynia (vaginal burning sensation without sexual activity), and stress urinary incontinence episodes, as evidenced in a recent article published in the Journal of Urology and Research. Full text available at: Journal of Urology and Research: Microfractured and Purified Adipose Tissue (Lipogems system) Injections for Treatment of Atrophic Vaginitis For more information, please contact us at 02 76280736

Telangiectasias (from Greek, meaning 'dilation of vessel endings') are dilated capillaries and small blood vessels visible on the skin surface. These vascular manifestations affect both men and women, with documented higher prevalence in females and increasing occurrence with age. Beyond cosmetic concerns, when accompanied by symptoms, they may represent the initial stage of chronic venous disease, as stated in the latest guidelines of the Italian Society of Phlebology (SIF). Pathophysiology of Venous Degeneration Various predisposing factors including genetics, family history, prolonged standing, and estrogen-progestin medications contribute to venous wall deterioration. The venous wall becomes less elastic and venous valves less competent, reducing the efficiency of blood return to the right atrium. This functional deficit leads to reflux and blood volume accumulation in the lower extremity venous circulation, resulting in increased venous pressure and collateral vessel dilation. Clinical manifestations include leg fatigue, visible capillaries, prominent veins, and in severe cases, varicose veins. TRAP Technology and Mechanism TRAP (Three-dimensional Regenerative Ambulatory Phlebotherapy) addresses the entire superficial and perforating venous system affected by intrinsic wall weakness. The procedure involves endovenous injection of precisely diluted sodium salicylate solution administered over multiple sessions. Veins are visualized using transillumination technology. The treatment aims to restore proper consistency and linear flow to thinned, inflamed, and weakened vein walls while recovering valvular competence to promote proper blood circulation. Comprehensive treatment of the entire circulatory system is essential to prevent recurrence. Treatment Protocol Post-treatment compression therapy (140 denier stockings) is required between sessions and for one month after completing the therapeutic cycle. The procedure does not restrict physical or social activities. Treatments are optimally performed during autumn and winter months, treating one limb at a time.

Image Regenerative Clinic combines regenerative medicine with highly specialized professionals for an innovative and personalized solution Chronic pain affects 20% of the adult population. Back pain alone affects 1 in 3 adults at least once in their lifetime, becoming chronic in 25% of cases, creating serious medical issues and social and work isolation. To understand how common pain disease is, consider conditions like osteoarthritis, back pain, cervical pain, fibromyalgia, or neuropathic pain. In such cases, a diagnosis and specialized treatment specific to the pain condition must be established and always personalized based on patient characteristics. Treating pain is therefore not only a moral imperative but also a medical-health imperative that requires a multidisciplinary approach and cutting-edge technologies. The first specialized regenerative medicine center for pain treatment established at Istituto Image Regenerative medicine has now thoroughly demonstrated its ability not only to reduce/control chronic inflammation but also to regenerate tissues, resolving the damage caused by such inflammation. Lipogems, patented by Prof. Tremolada, director of Image Regenerative Clinic, represents one of the most validated therapeutic approaches available in regenerative medicine. Regenerative medicine represents one of the most promising responses to both acute pain control (reducing the risk of developing chronic pain) and chronic pain, as it provides a method for long-term control of inflammation - the very element that causes acute pain to become chronic and transforms from a symptom into a true disease: chronic pain. Within regenerative medicine, Lipogems has proven to be the most effective choice, demonstrated by dozens of international studies, particularly in chronic osteoarthritis (one of the most frequent causes of chronic pain), where it succeeds not only in reducing pain but also in regenerating tissue, promoting natural healing of pain disease. To establish the first true regenerative pain medicine center, it is necessary to combine this major therapeutic innovation with specific pain therapy expertise, not only to diagnose the cause of pain but also to utilize regenerative medicine through highly innovative imaging methods to ensure personalized and targeted therapy for patients. This is combined with rehabilitation for pain patients to restore true well-being to individuals who have suffered from chronic pain. Pain therapy means restoring dignity and quality of life to pain patients The regenerative pain medicine center, through the introduction of a pain therapy specialist and the use of a widely proven method effective in treating chronic osteoarthritis, treats not only articular pathologies of the hip, knee, and shoulder but also all arthritic pain of the spine and issues related to occipital headache and peripheral nerve lesions.

Lipogems is an innovative technology that harnesses the natural and potent reparative capacity of adipose tissue reserves. This procedure can serve as an alternative or complementary tool to surgical intervention in supporting tissue repair processes. The fields of application include orthopedics, aesthetics, chronic wounds, gynecology, and burns. Lipogems Worldwide Lipogems, an Italian excellence, is currently present in 27 countries worldwide and is a technique patented by Prof. Carlo Tremolada, Scientific Director of Image The Urban Medi Spa. Image is Italy's premier regenerative clinic and, through Prof. Tremolada and his team of highly specialized physicians, maintains the most extensive international experience in the field. Lipogems and RockStar London: Regenerative OsteoChondral Congress Prof. Tremolada's regenerative medicine was presented in London at an event organized in collaboration with Lipogems International and Joint Operations. The meeting focused on regenerative medicine in orthopedics and the possibility of avoiding or delaying prosthetic surgery through regenerative intervention. Distinguished experts from around the world participated, including Prof. Adrian Wilson, Dr. Konrad Slynarski who has been using Lipogems in orthopedic surgery for two years, Prof. Arnold Caplan, one of the leading experts in mesenchymal stem cells, Prof. Carlo Tremolada, inventor of the Lipogems method, and many others. The Lipogems technology is distinguished by its ability to preserve adipose tissue integrity during processing, maintaining the vascular network and extracellular matrix intact. The processed tissue contains a high concentration of mesenchymal stem cells, which can differentiate into various cell types and promote tissue repair through the release of growth factors and cytokines.

Rexonage is an electromedical device based on Molecular Quantum Resonance (MQR) technology, which employs low-intensity, high-frequency electrical fields. Its function is to stimulate tissue regeneration and restore lost physiological balance caused by trauma, pathologies, or aging. Rexonage Promotes Cellular Stimulation The uniqueness and innovation of this device stem from its operating frequencies, ranging between 4 and 64 MHz. Studies have demonstrated that when an MQR electrical field is applied to tissue, it does not cause tissue heating but rather facilitates an almost completely athermal energy transfer, promoting cellular-level stimulation. In vitro studies conducted to understand how MQR stimulates cellular processes have identified three potential types of stimulation: This frequency range produces resonance between specific molecular bonds of cellular components, causing their temporary disruption or weakening. The cellular membrane modification is transient, and cells return to their initial state once the electrical field is removed. This temporary modification creates a form of cellular massage that stimulates regeneration and provides anti-inflammatory effects. Conditions Treated with Rexonage Beyond aesthetic applications, MQR is utilized in treating post-surgical edema, as an analgesic-rehabilitative therapy for degenerative conditions, and is frequently combined with Lipogems treatment. Primary indications include: tendinopathies, muscle injuries, osteoarthritis, chronic pain, post-surgical edema, and pathological scarring. In conclusion, Rexonage is a non-invasive treatment with no known side effects, capable of reducing pain and improving functional limitations.

The Lipogems system, patented by Prof. Tremolada in 2010, is an FDA-cleared advanced technology that utilizes the patient's adipose cells to support the healing process. It is currently present in dozens of countries and is used by highly qualified orthopedic surgeons and physicians affiliated with major universities and private clinics. Advantages of Lipogems Technology Adipose tissue contains one hundred to five hundred times more reparative cells compared to other similar tissues. Adipose cells are easy to harvest from the patient and present minimal risk of rejection and infection. The technology is particularly indicated for patients affected by: - Degenerative processes of articular cartilage (degenerative chondropathy) - Meniscal degeneration and inflammatory lesions - Problems affecting tendon and ligament structures - Sports-related joint injuries Simple and Effective Procedure The procedure takes approximately one hour and involves: 1. Harvesting adipose tissue (usually from abdomen or flanks) 2. Minimal processing in closed system with saline solution 3. Micro-fragmentation of tissue 4. Infiltration into target areas under ultrasound guidance Scientific Evidence Lipogems technology is supported by solid scientific and clinical evidence. As emphasized by Dr. Kennedy from the Hospital for Special Surgery in New York, patients are entered into a database to continuously evaluate outcomes. Research continues to explore the potential of this technology in regenerative medicine. Patient Advisory It is essential to rely only on qualified orthopedic physicians and verify that the technology used is FDA-approved. Patients should be wary of clinics offering uncertified stem cell treatments or miraculous promises of cartilage regrowth.

V Joint Preservation Congress - Warsaw Following last year's success, Prof. Tremolada returns to Warsaw for the world congress. Most treatments used for degenerative diseases are unable to maintain full joint functionality and physical fitness in patients. Due to the continuous increase in these conditions, physicians worldwide are seeking effective alternative treatments. New therapies should be capable of reducing patient pain and extending physical activity. The conference is led by world-renowned experts - physicians and scientists including Prof. Carlo Tremolada - who are leaders in research, development, and application of new technologies for treating degenerative diseases and traumas that lead to their development. Joint Preservation with the Lipogems Method Mesenchymal stem cells assist in healing from trauma and injuries, and Lipogems is the most efficient, rapid, and safe system for supporting recovery and healing by naturally delivering them to the site through autologous adipose tissue transplantation. Patients with articular cartilage lesions may experience joint pain and reduced functionality, often progressing to end-stage osteoarthritis, which is among the top 10 causes of disability worldwide. Lipogems accelerates the natural tissue regeneration and repair process by preserving adipose tissue integrity and its vascular network. The system gently processes autologous adipose tissue while maintaining its biological and structural properties. This technology enables conservative treatment of various degenerative joint conditions including shoulder, knee, ankle, and hip, offering a minimally invasive therapeutic alternative.

About 10% of people with foot pain suffer from this condition, which has been prevalent since the 1800s when Dr. Thomas G. Morton systematically outlined its clinical and pathogenetic characteristics, giving the syndrome his name. What is Morton's Neuroma? Morton's Neuroma is one of the most insidious causes of forefoot pain, characterized by electric shock-like sensations radiating to the metatarsal region, toe tingling, and the typical uncomfortable sensation of having a pebble in the shoe. Neuroma is an improper term describing an epineural fibro-cicatricial thickening of an interdigital nerve (responsible for cutaneous sensitivity of the toes) caused by chronic mechanical trauma. The neuroma is located in 80% of cases in the third metatarsal space (between third and fourth toes), where the metatarsal heads and deep metatarsal ligament are more mobile and create continuous friction on the nerve. Women are more frequently affected due to constrained foot positions in high heels with narrow toes, resulting in plantar load imbalance. Other predisposing conditions include hallux valgus, ligamentous laxity, certain sports activities, and rheumatoid arthritis. Diagnosis is primarily clinical (though radiological examinations are often required to exclude other articular and bone pathologies), and traditional therapy has been somewhat uncertain. Treatment ranges from custom orthopedic insoles created after baropodometric examination, NSAIDs, and local anesthetic and corticosteroid injections in early stages, to sclero-alcoholization or surgical intervention in more persistent cases resistant to previous treatments, often without achieving significant benefit, requiring about 30 days of recovery and resulting in residual toe sensitivity deficits. Lipogems: The Innovative Solution Lipogems, the technology that optimizes and amplifies tissue repair and regenerative mechanisms through microfragmented adipose tissue transplantation, utilizes the analgesic, anti-inflammatory, and antifibrotic properties of exosomal molecules produced and released by mesenchymal stem cells from adipose tissue to resolve metatarsal pain, restoring adequate ambulatory function and improving quality of life without requiring surgical intervention. The procedure is performed under local anesthesia: after harvesting a minimal amount of adipose tissue from the abdominal region or flanks, it is processed using the Lipogems technique to obtain the minimally manipulated final product, which can be easily injected around the interdigital nerve at the third metatarsal space. The procedure takes approximately 45 minutes and requires no hospitalization. Clinical results demonstrate that Lipogems treatment provides significant pain relief and improved foot functionality in most treated patients, with effects maintaining over time due to the regenerative properties of the processed adipose tissue.